Comparison of antioxidative capacities and inhibitory effects on cholesterol biosynthesis of quercetin and potential metabolites

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
G GlässerR Gebhardt

Abstract

The flavonol quercetin is known to be rapidly metabolized after ingestion by enterocytes and bacteria in the intestinal tract which may influence the biological, e.g. antioxidative potency of this compound. Therefore, quercetin and several of its possible metabolites were compared with regard to their antioxidant activity and their capacity to inhibit hepatocellular cholesterol biosynthesis. Using the 2,2,-diphenylpicrylhydrazyl radical scavenger assay, all compounds with an ortho diphenolic structure acted as strong antioxidants. In contrast, in a cellular assay focusing on lipid peroxidation in cultured rat hepatocytes challenged with tert.-butylhydroperoxide only the lipophilic compounds quercetin and 3,4-dihydroxytoluene were active. Concerning the inhibition of cholesterol biosynthesis, 3,4-dihydroxytoluene surprisingly mimicked the effect of quercetin in primary rat hepatocytes, but much less so in HepG2 cells. All other metabolites were almost ineffective in both cell types. These results suggest that some of the biological functions of flavonoids detectable by in vitro assays may persist in vivo as long as comparably potent metabolites are systemically present.

References

Jan 1, 1990·Free Radical Biology & Medicine·Y T ChenY Ju
Jan 1, 1990·Methods in Enzymology·H Esterbauer, K H Cheeseman
Jul 1, 1995·The Journal of Nutrition·C ManachC Rémésy
Jun 23, 1994·Biochimica Et Biophysica Acta·R GebhardtK G Wagner
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B N AmesT M Hagen
Jan 1, 1995·Biochemical Society Symposium·C Rice-Evans
Jan 1, 1996·Free Radical Biology & Medicine·C A Rice-EvansG Paganga
Oct 22, 1998·Advances in Experimental Medicine and Biology·J A Vinson
Nov 5, 1998·Free Radical Research·J E Brown, C A Rice-Evans
Dec 16, 1998·The British Journal of Nutrition·A T DiplockJ Viña-Ribes
Mar 30, 1999·Journal of Natural Products·M WangC T Ho
Apr 15, 1999·Proceedings of the Society for Experimental Biology and Medicine·R L Prior, G Cao
May 27, 1999·The Proceedings of the Nutrition Society·H Wiseman
Sep 11, 1999·FEBS Letters·J P SpencerC Rice-Evans
Oct 29, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P C Hollman, M B Katan
Dec 10, 1999·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·E U Graefe, M Veit
Feb 3, 2000·Mechanisms of Ageing and Development·T Osawa
Nov 18, 2000·European Journal of Clinical Nutrition·S P BoyleA R Collins
Oct 1, 1997·Toxicology in Vitro : an International Journal Published in Association with BIBRA·R Gebhardt, M Fausel

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Citations

Aug 24, 2010·Lipids in Health and Disease·Saf-ur Rehman MandukhailAnwarul-Hassan Gilani
Sep 19, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M-P GonthierA-M Aura
Aug 24, 2006·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·T Wegener, H Wagner
Feb 3, 2015·Cell Biology International·Chunjin LiXu Zhou
Jun 19, 2013·Environmental Toxicology and Pharmacology·Asmaa I MatoukMohamed A El-Moselhy
Jun 11, 2014·Critical Reviews in Food Science and Nutrition·Hafiz Ansar Rasul SuleriaNauman Khalid
Mar 11, 2009·Anais Da Academia Brasileira De Ciências·Alexandre KanashiroYara M Lucisano-Valim
Nov 22, 2005·Free Radical Research·Sanja Pavlica, Rolf Gebhardt
May 16, 2018·Nutrients·Liangkui LiChris Seal
Nov 1, 2002·Phytotherapy Research : PTR·Gareth GriffithsBrian Smith
Apr 14, 2011·Nutrition Research and Practice·Kyung-Hea LeeMin-Jeong Shin
Apr 5, 2003·The Journal of Pharmacology and Experimental Therapeutics·Kyoji MoritaYoshinari Ohnishi
Jul 15, 2005·Molecular and Cellular Biochemistry·Rajesh AroraRakesh Kumar Sharma
Mar 29, 2003·The American Journal of Clinical Nutrition·Laurent Y RiosAugustin Scalbert
May 29, 2003·The Journal of Nutrition·Marie-Paule GonthierAugustin Scalbert
May 13, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marcello LocatelliGiustino Orlando
Mar 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Maryam Bahram-Parvar, Loong-Tak Lim
Sep 1, 2018·Comprehensive Reviews in Food Science and Food Safety·Gary WilliamsonAlan Crozier
May 14, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Marie-Paule GonthierAugustin Scalbert
Dec 11, 2003·Journal of Agricultural and Food Chemistry·Johanna GrassmannErich F Elstner

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