Comparison of Antiretroviral Regimens: Adverse Effects and Tolerability Failure that Cause Regimen Switching

Infection & chemotherapy
Min Jung KimJong Myung Lee

Abstract

The efficacy of antiretroviral therapy (ART) has improved, and the adverse effects of antiretroviral drugs have been reduced. However, these adverse effects still significantly influence patient compliance, increasing the risk of tolerability failure. Therefore, we investigated the adverse effects and tolerability failure causing changes in the first ART regimen, and identified the regimens that were most vulnerable to switching. We enrolled patients with human immunodeficiency virus (HIV) who commenced their first ART between January 1, 2011 and July 30, 2014. Patients who started their first ART regimen at the Kyungpook National University Hospital were included in the study if they were aged ≥18 years and were followed-up for ≥12 weeks. The primary dependent variable was the duration of treatment on the same ART regimen. We analyzed the maintenance rate of the first ART regimen based on the treatment duration between these groups using survival analysis and log rank test. The frequency of the adverse effects of ART regimens was analyzed by multiple response data analysis. During the investigation period, 137 patients were enrolled. Eighty-one patients were maintained on the initial treatment regimen (59.1%). In protease inhi...Continue Reading

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Citations

Feb 24, 2018·Journal of the International Association of Providers of AIDS Care·David LessardBertrand Lebouché
Nov 21, 2017·PloS One·Victor SinganoJoep J van Oosterhout
Sep 15, 2017·Headache·Pedro Augusto Sampaio Rocha-FilhoUlisses Ramos Montarroyos
Jan 25, 2019·Expert Opinion on Pharmacotherapy·Amedeo Capetti, Giuliano Rizzardini
Oct 14, 2017·Infection & chemotherapy·Min Jung KimUNKNOWN Korea HIV/AIDS Cohort Study
Oct 14, 2017·Infection & chemotherapy·Heawon AnnShin Woo Kim
Jul 4, 2020·Infection & chemotherapy·June Myung KimBum Sik Chin
Sep 10, 2020·Curēus·Nicholas ZareifopoulosDimitrios Velissaris
Oct 24, 2020·Chembiochem : a European Journal of Chemical Biology·Siriluk RatanabunyongSupa Hannongbua
Aug 31, 2021·Journal of Medicinal Chemistry·Nicole PributEric J Miller

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