Comparison of arterial and venous blood gases and the effects of analysis delay and air contamination on arterial samples in patients with chronic obstructive pulmonary disease and healthy controls

Respiration; International Review of Thoracic Diseases
T M O'ConnorA El-Gammal

Abstract

Arterial blood gases (ABGs) are often sampled incorrectly, leading to a 'mixed' or venous sample. Delays in analysis and air contamination are common. We measured the effects of these errors in patients with chronic obstructive pulmonary disease (COPD) exacerbations and controls. Arterial and venous samples were analyzed from 30 patients with COPD exacerbation and 30 controls. Venous samples were analysed immediately and arterial samples separated into non-air-contaminated and air-contaminated specimens and analysed at 0, 30, 60, 90 and 180 min. Mean venous pH was 7.371 and arterial pH was 7.407 (p < 0.0001). There was a correlation between venous and arterial pH (r = 0.5347, p < 0.0001). The regression equation to predict arterial pH was: arterial pH = 4.2289 + 0.43113 · venous pH. There were no clinically significant differences in arterial PO₂ associated with analysis delay. A statistically significant decline in pH was detected at 30 min in patients with COPD exacerbation (p = 0.0042) and 90 min in controls (p < 0.0001). A clinically significant decline in pH emerged at 73 min in patients with COPD exacerbation and 87 min in controls. Air contamination was associated with a clinically significant increase in PO₂ in all samp...Continue Reading

Associated Clinical Trials

Citations

Nov 12, 2013·Diabetes Technology & Therapeutics·Christina SchmidGuido Freckmann
Jan 5, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Anthony L ByrnePaul S Thomas
Dec 10, 2017·Journal of Biomechanical Engineering·Keith J GoochBenjamin W Scandling
Mar 8, 2019·Journal of Diabetes Science and Technology·Annette BaumstarkGuido Freckmann
Mar 28, 2019·Critical Reviews in Clinical Laboratory Sciences·K Berend, A J Duits
Jan 2, 2015·Emergency Medicine Journal : EMJ·Anne-Maree Kelly
Dec 20, 2013·Journal of Diabetes Science and Technology·Guido FreckmannCornelia Haug
Oct 19, 2019·Biochemia Medica·Antonija Perović, Marina Njire Bratičević

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