Comparison of association of glomerular filtration rate with metabolic syndrome in a community-based population using the CKD-EPI and MDRD study equations

Clinica Chimica Acta; International Journal of Clinical Chemistry
Namki HongSeok-Min Kang

Abstract

Targeting metabolic syndrome (MetS) in early chronic kidney disease (CKD) is essential to reduce cardiovascular complications. We compared the association of kidney function estimated by two glomerular filtration rate (GFR) equations with MetS in community population. We analyzed 12,700 participants from 2009 to 2010 the Korea National Health Survey data. GFR was estimated using the CKD Epidemiology Collaboration equation (GFR(CKD-EPI)) and the Modification of Diet in Renal Disease study equation (GFR(MDRD)). The prevalence of MetS increased from the highest GFR category (>105 ml/min/1.73 m(2)) to the lowest (<60 ml/min/1.73 m(2)) using both equations (GFR(CKD-EPI), 14.1% to 62.3%; GFR(MDRD), 18.4% to 62.9%). Participants reclassified to higher GFR(CKD-EPI) category (upward) from GFR(MDRD) had lower prevalence of MetS than those moved downward (Net reclassification improvement 13.7%, P<0.001). Compared with GFR ≥105 ml/min/1.73 m(2), mildly impaired GFR(CKD-EPI) (75-89 ml/min/1.73 m(2)) was independently associated with increased odds of MetS (OR 1.30, 95% CI 1.09-1.56, P=0.003) in multivariate analysis, whereas GFR(MDRD) was not (OR 1.08, 95% CI 0.92-1.27, P=0.344). Compared with GFR(MDRD), GFR(CKD-EPI) showed better associati...Continue Reading

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Citations

Mar 29, 2014·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·T Kawada
May 3, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tomoyuki Kawada
Apr 15, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Tomoyuki Kawada
Aug 5, 2017·Occupational and Environmental Medicine·Kyoung-Nam KimYun-Chul Hong

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