Abstract
Targeting metabolic syndrome (MetS) in early chronic kidney disease (CKD) is essential to reduce cardiovascular complications. We compared the association of kidney function estimated by two glomerular filtration rate (GFR) equations with MetS in community population. We analyzed 12,700 participants from 2009 to 2010 the Korea National Health Survey data. GFR was estimated using the CKD Epidemiology Collaboration equation (GFR(CKD-EPI)) and the Modification of Diet in Renal Disease study equation (GFR(MDRD)). The prevalence of MetS increased from the highest GFR category (>105 ml/min/1.73 m(2)) to the lowest (<60 ml/min/1.73 m(2)) using both equations (GFR(CKD-EPI), 14.1% to 62.3%; GFR(MDRD), 18.4% to 62.9%). Participants reclassified to higher GFR(CKD-EPI) category (upward) from GFR(MDRD) had lower prevalence of MetS than those moved downward (Net reclassification improvement 13.7%, P<0.001). Compared with GFR ≥105 ml/min/1.73 m(2), mildly impaired GFR(CKD-EPI) (75-89 ml/min/1.73 m(2)) was independently associated with increased odds of MetS (OR 1.30, 95% CI 1.09-1.56, P=0.003) in multivariate analysis, whereas GFR(MDRD) was not (OR 1.08, 95% CI 0.92-1.27, P=0.344). Compared with GFR(MDRD), GFR(CKD-EPI) showed better associati...Continue Reading
References
May 9, 1998·Kidney International·D FliserE Ritz
May 8, 2002·The Journal of Clinical Endocrinology and Metabolism·Reinhard FenebergFranz Schaefer
Feb 6, 2004·Annals of Internal Medicine·Jing ChenJiang He
May 27, 2004·Diabetes Care·Tara M WallaceDavid R Matthews
Sep 15, 2005·Circulation·Scott M GrundyUNKNOWN National Heart, Lung, and Blood Institute
Jun 9, 2006·The New England Journal of Medicine·Lesley A StevensAndrew S Levey
Aug 16, 2006·Annals of Internal Medicine·Andrew S LeveyUNKNOWN Chronic Kidney Disease Epidemiology Collaboration
Jun 15, 2007·Statistics in Medicine·Michael J PencinaRamachandran S Vasan
Sep 15, 2007·Journal of the American Society of Nephrology : JASN·Lesley A StevensAndrew S Levey
Jan 24, 2008·Circulation·Ralph B D'AgostinoWilliam B Kannel
Oct 7, 2008·Diabetes Care·Andrea O Y LukUNKNOWN Hong Kong Diabetes Registry
Oct 8, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Seungho RyuKijung Yoon
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Oct 7, 2010·Journal of Diabetes·Xiongzhong Ruan, Youfei Guan
Dec 15, 2010·Kidney International·Andrew S LeveyKai-Uwe Eckardt
Jan 25, 2011·Clinical Nephrology·C-C LeeM-S Wu
Jul 12, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Lesley A StevensPeter A McCullough
May 24, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Boon Wee TeoEvan J C Lee
Jun 16, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·XueJing WangFang Wang
Aug 2, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·LiPing JiangNingLi Wang
Aug 20, 2011·Clinical Journal of the American Society of Nephrology : CJASN·George ThomasSankar D Navaneethan
May 10, 2012·JAMA : the Journal of the American Medical Association·Kunihiro MatsushitaUNKNOWN Chronic Kidney Disease Prognosis Consortium
Aug 15, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Hannah S KilbrideEdmund J Lamb
Nov 30, 2012·International Journal of Cardiology·Jaewon OhUNKNOWN KorHF Registry
Dec 1, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Xianglei KongUNKNOWN Chinese eGFR Investigation Collaboration
Jul 5, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Belén PonteMurielle Bochud
Citations
Mar 29, 2014·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·T Kawada
May 3, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tomoyuki Kawada
Aug 15, 2014·International Journal of Cardiology·Jaewon OhDonghoon Choi
Apr 15, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Tomoyuki Kawada
Aug 5, 2017·Occupational and Environmental Medicine·Kyoung-Nam KimYun-Chul Hong
Feb 23, 2021·International Journal of Endocrinology and Metabolism·Pouria MousapourFarhad Hosseinpanah