Comparison of atenolol and oxprenolol in patients with angina or hypertension and co-existent chronic airways obstruction

British Journal of Clinical Pharmacology
W H PerksJ M Cruickshank

Abstract

1 The effects of atenolol (50 mg and 100 mg) and oxprenolol (80 mg) on respiratory function were studied in ten patients with angina pectoris or hypertension complicated by chronic airways obstruction. 2 In patients with "fixed" airways obstruction, neither atenolol nor exprenolol significantly affected airways resistance. 3 In patients with "labile" airways obstruction, atenolol did not produce a significant increase in airways obstruction, whereas oxprenolol did. 4 Following isoprenaline challenge (1500 microgram by inhalation), atenolol permitted full bronchodilatation, whereas oxprenolol almost completely blocked the action of isoprenaline. 5 Partial agonist activity appears to be of less clinical importance than cardioselectivity.

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Related Concepts

Chronic Disease
Respiratory Physiology
Propanolamines
Oxprenolol
Angina Pectoris
Hypertensive Disease
Isoproterenol
Respiratory System Function
Agonist
Clinical Trials

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