Comparison of atenolol and oxprenolol in patients with angina or hypertension and co-existent chronic airways obstruction

British Journal of Clinical Pharmacology
W H PerksJ M Cruickshank


1 The effects of atenolol (50 mg and 100 mg) and oxprenolol (80 mg) on respiratory function were studied in ten patients with angina pectoris or hypertension complicated by chronic airways obstruction. 2 In patients with "fixed" airways obstruction, neither atenolol nor exprenolol significantly affected airways resistance. 3 In patients with "labile" airways obstruction, atenolol did not produce a significant increase in airways obstruction, whereas oxprenolol did. 4 Following isoprenaline challenge (1500 microgram by inhalation), atenolol permitted full bronchodilatation, whereas oxprenolol almost completely blocked the action of isoprenaline. 5 Partial agonist activity appears to be of less clinical importance than cardioselectivity.


Jan 1, 1991·Cardiovascular Drugs and Therapy·A E Tattersfield
Jan 1, 1984·European Journal of Clinical Pharmacology·H W ClagueS G Carruthers
Mar 26, 1979·European Journal of Clinical Pharmacology·V M OhP Turner
Jan 1, 1980·Pharmacology & Therapeutics·B N Prichard, C W Owens
Jan 1, 1983·Pharmacology & Therapeutics·A J Scriven, P J Lewis
Jan 1, 1990·Pharmacology & Therapeutics·T H Pringle, J G Riddell
Aug 1, 1978·British Journal of Clinical Pharmacology·V M OhJ Wadsworth
Jan 1, 1981·European Journal of Clinical Pharmacology·A P Greefhorst, C L van Herwaarden
Jan 1, 1984·European Journal of Clinical Pharmacology·J W LammersC L van Herwaarden
May 1, 1980·Chest·D EzraT Rosenthal
Nov 1, 1986·British Journal of Clinical Pharmacology·J W LammersC L van Herwaarden
Sep 1, 1988·British Journal of Clinical Pharmacology·I Macquin-MavierA Harf
May 21, 2011·Journal of the American College of Cardiology·Nathaniel M HawkinsJohn J V McMurray
Apr 1, 1985·Chest·J BroquetasJ Soler
Aug 1, 1978·British Journal of Clinical Pharmacology·W H PerksJ M Cruickshank
Feb 1, 1978·British Journal of Clinical Pharmacology·D G McDevitt
Aug 1, 1978·British Journal of Clinical Pharmacology·D G McDevitt
Jan 1, 1982·British Journal of Clinical Pharmacology·R E RuffinJ H Alpers
Oct 20, 2005·The Cochrane Database of Systematic Reviews·S SalpeterE Salpeter
Aug 1, 1978·British Journal of Clinical Pharmacology·C R Kumana


Jul 19, 1975·Lancet·C R KumanaJ Hamer
Dec 4, 1971·Lancet·H J Waal-Manning, F O Simpson
Sep 26, 1970·Lancet·C Bernecker, I Roetscher
Jun 12, 1971·British Medical Journal·J W Paterson

Related Concepts

Chronic Disease
Respiratory Physiology
Angina Pectoris
Hypertensive Disease
Respiratory System Function
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