Comparison of Atlantic salmon individuals with different outcomes of cardiomyopathy syndrome (CMS)

BMC Genomics
Gerrit TimmerhausSven Martin Jørgensen

Abstract

Cardiomyopathy syndrome (CMS) is a severe disease of Atlantic salmon (Salmo salar L.) associated with significant economic losses in the aquaculture industry. CMS is diagnosed with a severe inflammation and degradation of myocardial tissue caused by a double-stranded RNA virus named piscine myocarditis virus (PMCV), with structural similarities to the Totiviridae family. In the present study we characterized individual host responses and genomic determinants of different disease outcomes. From time course studies of experimentally infected Atlantic salmon post-smolts, fish exhibited different outcomes of infection and disease. High responder (HR) fish were characterized with sustained and increased viral load and pathology in heart tissue. Low responder (LR) fish showed declining viral load from 6-10 weeks post infection (wpi) and absence of pathology. Global gene expression (SIQ2.0 oligonucleotide microarray) in HR and LR hearts during infection was compared, in order to characterize differences in the host response and to identify genes with expression patterns that could explain or predict the different outcomes of disease. Virus-responsive genes involved in early antiviral and innate immune responses were upregulated equall...Continue Reading

References

Jan 1, 1997·Annual Review of Immunology·U BoehmJ C Howard
Jul 11, 2000·The Veterinary Record·H Rodger, T Turnbull
Jan 18, 2002·Journal of Applied Physiology·Kevin CulliganKay Ohlendieck
Oct 4, 2003·Diseases of Aquatic Organisms·Trygve T Poppe, Sverre L Seierstad
Feb 12, 2004·Bioinformatics·M J L de HoonS Miyano
Mar 1, 2006·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Takeshi Nitta, Yousuke Takahama
May 6, 2006·Marine Biotechnology·Sven Martin JorgensenTor Gjoen
Jun 1, 2007·Clinical and Vaccine Immunology : CVI·Michael J ZillioxDiane E Griffin
May 1, 2008·Nucleic Acids Research·Stefan GötzAna Conesa
Aug 30, 2008·Autoimmunity Reviews·Alessandra B Pernis
Jan 27, 2010·Diseases of Aquatic Organisms·C FritsvoldT T Poppe
Feb 13, 2010·Current Opinion in Immunology·Adam WilliamsStephanie C Eisenbarth
Jun 12, 2010·Immunological Reviews·Judy Lieberman
Jun 26, 2010·Nature Reviews. Immunology·Barry T Rouse, Sharvan Sehrawat
Jul 8, 2010·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Aleksei KrasnovSven Martin Jørgensen
Jul 20, 2010·Immunological Reviews·Craig M Walsh, Aimee L Edinger
Sep 29, 2011·BMC Genomics·Gerrit TimmerhausSven Martin Jørgensen

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Citations

Mar 4, 2014·BMC Physiology·Sven Martin JørgensenHarald Takle
May 15, 2013·General and Comparative Endocrinology·Aleksei KrasnovSven Martin Jørgensen
Nov 8, 2016·Developmental and Comparative Immunology·Mehrdad SobhkhezJorunn B Jørgensen
Jul 10, 2019·The Journal of Heredity·Borghild Hillestad, Hooman K Moghadam
Jul 10, 2019·The Journal of Heredity·Solomon BoisonNicholas Robinson
Mar 7, 2019·Scientific Reports·Lene Rydal SveenElisabeth Ytteborg

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Datasets Mentioned

BETA
BT072490.1
GPL10679
GSE36860

Methods Mentioned

BETA
GTPase
GTPases
electrophoresis
PCR
chips
feature extraction

Software Mentioned

BLAST
Cluster
EMBOSS
R
BestKeeper
BLAST2GO
BiNGO
GenePix Pro
LightCycler® 480
Cytoscape

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