Comparison of atomic-level and coarse-grained models for liquid hydrocarbons from molecular dynamics configurational entropy estimates

The Journal of Physical Chemistry. B
Riccardo BaronWilfred F van Gunsteren

Abstract

Molecular liquids can be modeled at different levels of spatial resolution. In atomic-level (AL) models, all (heavy) atoms can be explicitly simulated. In coarse-grained (CG) models, particles (beads) that represent groups of covalently bound atoms are used as elementary units. Ideally, a CG model should reproduce the thermodynamic and structural properties of the corresponding AL model after mapping to the lower-resolution scale. In the present work, two such models are investigated: (i) the classical GROMOS atomic-level model; (ii) a CG model recently proposed by Marrink et al., which maps approximately four non-hydrogen atoms to one bead [J. Phys. Chem. B 2004, 108, 750]. The study is restricted to n-alkanes whose aliphatic fragments are abundantly found in lipids of biological interest. Additionally, cis-9-octadecene is included, as a template chain of the lipid dioleoylphosphatidylcholine (DOPC). The two representations of molecules in the liquid phase are compared in terms of average molecular structures, extent of configurational space sampled, and single-molecule entropies. An approximate method is used to estimate the rotational contributions to the absolute configurational entropy. Good correspondence between the AL a...Continue Reading

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Citations

Nov 11, 2014·International Journal of Molecular Sciences·Qianqian YinYanjiang Qiao
Jan 3, 2016·The Journal of Chemical Physics·Thomas T FoleyW G Noid
Sep 4, 2016·Biochimica Et Biophysica Acta·Virginia MiguelMarcos A Villarreal
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Feb 10, 2007·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Riccardo BaronWilfred F van Gunsteren
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Aug 4, 2006·The Journal of Physical Chemistry. B·Riccardo BaronWilfred F van Gunsteren

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