PMID: 6401417Jan 1, 1983Paper

Comparison of bacterial adherence to ciliated and squamous epithelial cells obtained from the human respiratory tract

The American Review of Respiratory Disease
M S NiedermanH Y Reynolds

Abstract

Previous in vitro studies have suggested that bacterial adherence to buccal squamous epithelial cells may be a mechanism involved in postoperative colonization of the oropharynx. However, the relationship between bacterial binding to oral epithelial and ciliated respiratory cells is unknown. To investigate bacterial binding to other cells in the human respiratory tract, we measured adherence of Pseudomonas seruginosa to ciliated cells (from nose and trachea) and compared this to squamous cells (from buccal mucosa), Cell samples were collected from 16 noncolonized individuals undergoing either elective surgery or volunteer bronchoscopy. Adherence (mean +/- SEM) to tracheal cells (4.6 +/- 0.8 bacteria per cell) and to nasal cells (4.7 +/- 0.6 bacteria per cell) was similar. These values significantly (p less than 0.001) exceeded buccal cell adherence (0.9 +/- 0.2 bacteria per cell). Because cells from ciliated surfaces bind more bacteria than cells from squamous surfaces, bacterial adherence at these respiratory sites may involve different mechanisms. The enhanced bacterial attachment to ciliated cells may assume pathogenic importance when mucociliary function is impaired.

Citations

May 1, 1992·Postgraduate Medical Journal·R H Gunawardana
Dec 1, 1991·American Journal of Respiratory Cell and Molecular Biology·M M GrantA M Fein
Feb 16, 1984·The New England Journal of Medicine·R S GoldsteinE A Phillipson
Apr 27, 2017·FEMS Microbiology Letters·Charlotte VolgersFrank R M Stassen
Jan 1, 1990·Intensive Care Medicine·D M Geddes
Jan 1, 1986·American Journal of Industrial Medicine·D SheppardC Becker
Jul 1, 1996·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·F Bert, N Lambert-Zechovsky
Dec 1, 1985·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology·E L ElsheikhB Wretlind
Nov 1, 1985·Environmental Health Perspectives·R B Schlesinger
May 15, 2007·Current Opinion in Infectious Diseases·Paula RamirezAntoni Torres
Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·S PhilipponK Morgenroth
Mar 1, 1986·Infection Control : IC·M Fishman
May 16, 1998·Acta Oto-laryngologica·A EbenfeltC Lundberg
Jan 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M S Niederman
Jan 1, 1990·Critical Reviews in Toxicology·R B Schlesinger
Jan 1, 1984·Journal of Toxicology and Environmental Health·M Lippmann, R B Schlesinger
Jan 7, 2021·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Tomohiro OishiKazunobu Ouchi
Jun 1, 1987·Infection and Immunity·A L FranklinR T Irvin
Dec 1, 1994·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·G Piatti
Jul 1, 1990·Infection and Immunity·N BakerC Svanborg-Edén
Oct 21, 1998·Infectious Disease Clinics of North America·R McEachern, G D Campbell
Jan 1, 1990·Chest·M S NiedermanD E Schultz
Jun 26, 2009·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Hiroyuki KobayashiShin Kawai

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