Abstract
Idiopathic pulmonary arterial hypertension (PAH) is usually associated with a poor outcome but the prognosis with other forms of PAH is not well-described. Advances in therapy have furthered clouded the disease course. We sought to determine the baseline indicators of prognosis in patients with PAH. We reviewed the records of patients with PAH followed up at our institution to identify those who died within 2 years (reduced survival group; n = 21) and those who survived >5 years (long survival group; n = 60). The groups were compared for prognostic significance of the baseline clinical parameters. The reduced survival group were older (p = 0.001) and more likely to have scleroderma-associated PAH (p = 0.01), have pericardial effusion (p = 0.01), have a shorter 6-minute walk test (6MWT) distance (p = 0.001), to require oxygen during 6MWT (p = 0.02), have a worse World Health Organization functional class (p <0.001), and have greater serum brain natriuretic peptide levels (p = 0.01). Regression analysis showed age, World Health Organization functional class, 6MWT distance, the need for oxygen during the 6MWT, and renal disease to be independently associated with a poor prognosis. In conclusion, age, PAH etiology, World Health Org...Continue Reading
References
Aug 1, 1989·Circulation·S B EysmannP S Douglas
Feb 1, 1996·The New England Journal of Medicine·R J BarstUNKNOWN Primary Pulmonary Hypertension Study Group
May 30, 1998·The American Journal of Cardiology·T C YeoJ B Seward
Mar 21, 2001·Journal of cardiology·N NagayaK Kangawa
Jun 13, 2001·The European Respiratory Journal·G PacioccoM Rubenfire
Mar 30, 2002·Journal of the American College of Cardiology·Ronald J RaymondWalker Long
Sep 18, 2002·Circulation·Vallerie V McLaughlinStuart Rich
Nov 26, 2002·American Journal of Respiratory and Critical Care Medicine·Karl P KuhnIvan M Robbins
Feb 11, 2003·Chest·Steven M KawutStephen E Kimmel
Jul 14, 2004·Chest·Vallerie V McLaughlinUNKNOWN American College of Chest Physicians
Sep 1, 2004·Circulation·Sonia Velez-RoaPhilippe van de Borne
Feb 3, 2005·The European Respiratory Journal·V V McLaughlinL J Rubin
Mar 21, 2006·Respiratory Medicine·Christopher J LettieriAndrew F Shorr
Feb 14, 2007·Chest·Hanno H LeuchteJürgen Behr
Dec 25, 2007·Journal of the American College of Cardiology·Lori B Daniels, Alan S Maisel
Mar 22, 2008·American Journal of Respiratory and Critical Care Medicine·Paul R ForfiaPaul M Hassoun
May 7, 2008·Circulation·Sanjiv J ShahMardi Gomberg-Maitland
Feb 12, 2009·The Journal of Rheumatology·Sushmita Pamidi, Sanjay Mehta
Jun 3, 2009·The Journal of Rheumatology·Yoland SchoindreYannick Allanore
Jul 9, 2009·Journal of the American College of Cardiology·Gérald SimonneauRogério Souza
Aug 1, 2009·The European Respiratory Journal·S C MathaiP M Hassoun
Oct 3, 2009·The European Respiratory Journal·R Naeije, P van de Borne
Jun 30, 2010·Circulation·Raymond L BenzaMichael D McGoon
Citations
Aug 3, 2013·Current Opinion in Pulmonary Medicine·Sonja D Bartolome
Mar 20, 2013·Annals of the American Thoracic Society·Erika L LundgrinSerpil C Erzurum
Aug 1, 2014·Annals of Thoracic Medicine·Omar A Minai
Jun 13, 2014·BMC Research Notes·Koji YamamotoNobuyuki Ohte
Sep 25, 2015·Pulmonary Circulation·Omar A MinaiRaed A Dweik
Dec 18, 2013·Clinical and Translational Science·Adriano R TonelliRaed A Dweik
May 13, 2014·Drug Discovery Today·Neil McGlinchey, Andrew J Peacock
May 11, 2013·Pulmonary Circulation·Paul M HassounRonald J Oudiz
Mar 13, 2014·Pulmonary Circulation·Sandeep Sahay, Adriano R Tonelli
Mar 1, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Sankar D NavaneethanRaed A Dweik
Nov 14, 2019·Lung·Samantha L WronskiScott Manaker
Sep 15, 2017·Oncotarget·Shao-Liang ChenGregg W Stone
Jan 20, 2018·PloS One·Sebastian GreinerDerliz Mereles
Jun 13, 2014·Physiological Reports·Adriano R TonelliOmar A Minai
Feb 17, 2015·Echocardiography·Omar BatalMichael A Mathier
Jun 25, 2017·Lung·Abhishek GadreKristin B Highland