Comparison of baseline predictors of prognosis in pulmonary arterial hypertension in patients surviving ≤2 years and those surviving ≥5 years after baseline right-sided cardiac catheterization

The American Journal of Cardiology
Omar BatalOmar A Minai

Abstract

Idiopathic pulmonary arterial hypertension (PAH) is usually associated with a poor outcome but the prognosis with other forms of PAH is not well-described. Advances in therapy have furthered clouded the disease course. We sought to determine the baseline indicators of prognosis in patients with PAH. We reviewed the records of patients with PAH followed up at our institution to identify those who died within 2 years (reduced survival group; n = 21) and those who survived >5 years (long survival group; n = 60). The groups were compared for prognostic significance of the baseline clinical parameters. The reduced survival group were older (p = 0.001) and more likely to have scleroderma-associated PAH (p = 0.01), have pericardial effusion (p = 0.01), have a shorter 6-minute walk test (6MWT) distance (p = 0.001), to require oxygen during 6MWT (p = 0.02), have a worse World Health Organization functional class (p <0.001), and have greater serum brain natriuretic peptide levels (p = 0.01). Regression analysis showed age, World Health Organization functional class, 6MWT distance, the need for oxygen during the 6MWT, and renal disease to be independently associated with a poor prognosis. In conclusion, age, PAH etiology, World Health Org...Continue Reading

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Citations

Aug 3, 2013·Current Opinion in Pulmonary Medicine·Sonja D Bartolome
Dec 18, 2013·Clinical and Translational Science·Adriano R TonelliRaed A Dweik
May 11, 2013·Pulmonary Circulation·Paul M HassounRonald J Oudiz
Mar 13, 2014·Pulmonary Circulation·Sandeep Sahay, Adriano R Tonelli
Mar 1, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Sankar D NavaneethanRaed A Dweik

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