Comparison of Before and After Varicocelectomy Levels of Trace Elements, Nitric Oxide, Asymmetric Dimethylarginine and Malondialdehyde in the Seminal Plasma and Peripheral and Spermatic Veins

Biological Trace Element Research
Ali Riza KizilerAyse Acar

Abstract

Increased oxidative damage has been suggested to play an important role in the spermatogenesis and sperm function changes in patients with varicocele. However, changes in levels of nitric oxide (NO), asymmetric dimethylarginine (ADMA), malondialdehyde (MDA), iron (Fe), zinc (Zn) and copper (Cu) in blood and seminal plasma, and semen quality, are unknown. The aim of this study was to investigate the NO, ADMA, Fe, Cu, Zn and MDA levels from seminal plasma and peripheral and spermatic vein blood samples of patients with varicocele before and after varicocelectomy. In this before and after comparative study, 29 consecutive patients attending a training hospital in Tekirdag, Turkey, were recruited. MDA and NO levels were determined by spectrophotometric methods. The levels of ADMA were determined by enzyme-linked immunosorbent assay method. Trace element level was determined by atomic absorption spectrophotometric method. The levels of MDA in the seminal plasma and peripheral and spermatic vein samples were observed to decrease significantly in the comparison of before and after phases of the study group (p = 0.022, p = 0.001 and p = 0.034, respectively). Also, the levels of NO in the seminal plasma and spermatic vein samples decrea...Continue Reading

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Citations

Dec 9, 2015·Asian Journal of Andrology·Mariana CamargoRicardo Pimenta Bertolla
Jul 12, 2019·Human Fertility : Journal of the British Fertility Society·Fatemeh HaidariHossein Khadem Haghighian
Jun 3, 2018·Current Urology Reports·J Scott GabrielsenLarry I Lipshultz
Nov 5, 2020·Andrology·Mazdak RaziMohammad-Hossein Nasr-Eshafani
Feb 6, 2021·Hormone Molecular Biology and Clinical Investigation·Yasin SaygınAli Ünlü
Sep 3, 2017·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Mohammad Mostakhdem HashemiHamid Reza Joshaghani

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