Comparison of Bethesda cytopathology classification to surgical pathology across racial-ethnic groups

Head & Neck
Amishav BreslerThomas J Ow

Abstract

The Bethesda System standardized the reporting of thyroid cytopathology and created categories to provide an estimation of a nodule's risk of malignancy. There are limited data describing their utility in different racial-ethnic groups. A retrospective chart review of thyroid fine-needle aspirations (FNA) was performed within our health-care systems. Sensitivity, specificity, positive predictive value (PPV), and negative predictive values (NPVs) were calculated for the total cohort, and racial-ethnic groups. The sensitivity, specificity, PPV, and NPV of the entire cohort was 93%, 77%, 57%, and 97%. Among patients who underwent surgery, African Americans contained a high number of Bethesda II FNAs (63%) compared to Hispanics (48%) and whites (45%). The sensitivity, specificity, and NPV were comparable among groups, the PPV was lowest for African Americans (43%), followed by Hispanics (60%) and whites (69%). The Bethesda system's predictive value may differ among racial-ethnic groups.

References

Feb 5, 2008·Annals of Surgical Oncology·Luc G T MorrisMark D DeLacure
Nov 6, 2009·Thyroid : Official Journal of the American Thyroid Association·Edmund S Cibas, Syed Z Ali
May 15, 2010·American Journal of Surgery·Shaun R BrownBrad E Waddell
Feb 26, 2013·The Journal of Clinical Endocrinology and Metabolism·Matthew T OlsonMartha A Zeiger
Mar 23, 2013·Thyroid : Official Journal of the American Thyroid Association·Luc G T MorrisLouise Davies
Sep 26, 2013·Thyroid : Official Journal of the American Thyroid Association·Lorraine R ReitzelErich M Sturgis
Feb 6, 2015·JAMA Otolaryngology-- Head & Neck Surgery·Angelina MagreniDavid Goldenberg
Mar 31, 2016·Annals of Surgical Oncology·Lindsay E KuoRachel R Kelz

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Citations

Mar 31, 2021·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Sadia T AhmedVikas Mehta

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