Comparison of bleeding risks related to venous thromboembolism prophylaxis in laparoscopic vs open colorectal cancer surgery: a multicenter study in Japanese patients

American Journal of Surgery
Masayoshi YasuiClinical Study Group of Osaka University (CSGO), Colorectal Group

Abstract

Venous thromboembolism is the most common preventable cause of hospital death. The objective of this study was to clarify risk factors for postoperative bleeding related to thromboprophylaxis after laparoscopic colorectal cancer surgery. The study was conducted at 23 Japanese institutions and included patients with colorectal cancer who underwent laparoscopic or open surgery followed by fondaparinux treatment. We performed a retrospective analysis from a prospectively maintained database. We used multivariate analyses to evaluate clinical risk factors for prophylaxis-related bleeding events. After multivariate analysis, male gender, intraoperative blood loss of less than 25 mL, and a preoperative platelet count below 15 × 10(4)/μL were found to be independent risk factors in the laparoscopic surgery group. Only the preoperative platelet count was an independent risk factor in the open surgery group. Different prophylactic treatments for postoperative venous thromboembolism may be necessary in laparoscopic vs open surgery for colorectal cancer.

References

Jul 1, 1997·American Journal of Surgery·A T CohenM S Mohamed
Oct 3, 2003·Journal of the American College of Surgeons·Ninh T NguyenBruce M Wolfe
Jul 5, 2005·The Lancet Oncology·Ruben VeldkampUNKNOWN COlon cancer Laparoscopic or Open Resection Study Group (COLOR)
Sep 8, 2005·The Journal of Urology·Joseph A Smith
Mar 14, 2012·Journal of Vascular Surgery·Randall R De MartinoDavid H Stone
May 21, 2014·Surgery Today·Taishi HataUNKNOWN Multi-Center Clinical Study Group of Osaka, Colorectal Cancer Treatment Group (MCSGO)

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Citations

Jan 27, 2017·American Journal of Surgery·Caroline E JonesMelanie S Morris
Mar 7, 2017·Thrombosis Research·Dominique FargeBenjamin Brenner
Dec 12, 2018·Journal of Voice : Official Journal of the Voice Foundation·Samaneh Ebrahimi, Mandana Gholami

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