PMID: 15232803Jul 3, 2004Paper

Comparison of bolus remifentanil versus bolus fentanyl for induction of anesthesia and tracheal intubation in patients with cardiac disease

Journal of Cardiothoracic and Vascular Anesthesia
Hwan S JooRichard G Levene

Abstract

Large bolus-dose remifentanil may be advantageous for use during induction of anesthesia because of its short duration of effect. Currently, there are little data on the use of large bolus-dose remifentanil because of reports of severe bradycardia and hypotension. The purpose of this study is to compare the hemodynamic effects of bolus remifentanil versus fentanyl with glycopyrrolate for induction of anesthesia in patients with heart disease. A randomized, double-blinded study. A tertiary-care academic medical center. One hundred patients for coronary artery bypass or valvular surgery. Subjects received either (1) remifentanil, 5 microg/kg, with glycopyrrolate, 0.2 mg, or (2) fentanyl, 20 microg/kg, with 0.2 mg of glycopyrrolate, and both groups also received midazolam, 70 microg/kg, for induction of anesthesia. Heart rate, mean arterial pressure, systemic vascular resistance, and cardiac output were similar between the 2 groups during induction of anesthesia and tracheal intubation. The incidence of adverse events such as bradycardia (remifentanil 10%, fentanyl 10%), hypotension (remifentanil 16%, fentanyl 10%), and ischemia (remifentanil 0%, fentanyl 2%) were also similar. A greater percentage of patients in the remifentanil ...Continue Reading

References

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Citations

Aug 1, 2008·Medicinski pregled·Sanja VickovićSnezana Stanisavljević
Nov 7, 2012·Journal of Cardiothoracic and Vascular Anesthesia·Arne O Budde, Berend Mets
Aug 9, 2011·Journal of Cardiothoracic and Vascular Anesthesia·Massimiliano GrecoAlberto Zangrillo
Nov 10, 2007·Anaesthesia·R KomatsuC C Apfel
Jul 21, 2011·Fundamental & Clinical Pharmacology·Georgia FotopoulouTheodoros Xanthos
Feb 1, 2011·Current Therapeutic Research, Clinical and Experimental·Sang Hyun LeeWoo Seog Sim
Jul 17, 2020·Journal of Applied Physiology·Tiffany W DongRichard E Moon
Mar 15, 2019·Journal of Clinical Anesthesia·Lisa Q RongMario Gaudino

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