Comparison of bone prefabrication with vascularized periosteal flaps, hydroxyapatite, and bioactive glass in rats

Journal of Reconstructive Microsurgery
Burak ErsoyAyhan Numanoğlu

Abstract

Periosteal flaps possess osteoprogenitor cells and an osteoinductive potential that can be further augmented by combination with a biodegradable scaffold; therefore, various osteoconductive and osteostimulative biomaterials are frequently combined with periosteal flaps in studies of bone prefabrication. An experimental study was designed to determine and compare the contribution of bioactive glass and hydroxyapatite to osteoneogenesis in rats when combined with a periosteal flap. In 60 Sprague Dawley rats, saphenous artery periosto-fasciocutaneous island flaps were transposed to abdomen. In group 1, the flap was left alone, in group 2, an empty artificial pocket made of Gore-Tex (W. L. Gore & Associates, Inc.; Flagstaff, AZ) was sutured onto the periosteal layer, and in groups 3 and 4, the pocket was filled with bioactive glass and hydroxyapatite, respectively. Following sampling for histological analysis, a 4-point scoring system was used to grade inflammatory cell infiltration, osteogenesis, angiogenesis, and cell migration into the bioactive material. The combination of the periosteal flap with any of the bioactive materials resulted in significantly higher percentages of animals exhibiting osteogenesis (80% in hydroxyapatit...Continue Reading

Citations

Oct 26, 2016·EBioMedicine·Ru-Lin HuangQingfeng Li
Apr 5, 2017·Expert Opinion on Biological Therapy·Marta BarbaWanda Lattanzi
Oct 13, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Zhaohui PanJianli Wang

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