Comparison of botulinum toxin and propranolol for essential and dystonic vocal tremors

Clinics
Grazzia GuglielminoNoemi Grigoletto De Biase

Abstract

Vocal tremors, which cause social difficulties for patients, may be classified as resting or action tremors. Of the vocal action tremors, essential and dystonic tremors are the most common. Botulinum toxin and oral medications have been used to treat vocal tremors, but no comparative clinical trials have been performed. The aim of this study was to compare the effects of botulinum toxin injection and the oral administration of propranolol in the treatment of essential and dystonic vocal tremors. This clinical trial recruited 15 patients, divided into essential and dystonic vocal tremor groups. Patients in both groups received successive treatment with botulinum toxin and propranolol. The treatments were administered at different times; the order of treatment was randomly selected. Patients were assessed with flexible nasofibrolaryngoscopy and with perceptual and acoustic voice evaluations. A statistical significance level of 0.05 (5%) was used. Botulinum toxin produced statistically significant improvements in perceptual measures of vocal instability in patients with dystonic vocal tremors compared with baseline values and treatment with propranolol. The acoustic measure of variability in the fundamental frequency was significa...Continue Reading

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Citations

Oct 18, 2019·Journal of Speech, Language, and Hearing Research : JSLHR·Youri MarynJulie Barkmeier-Kraemer
Oct 3, 2019·Postgraduate Medical Journal·Soumya Sharma, Sanjay Pandey
Jan 25, 2020·Current Neuropharmacology·Hortensia Alonso-NavarroFélix J Jiménez-Jiménez
Dec 22, 2019·Dysphagia·Welber Chaves MororóNoemi Grigoletto De Biase
Sep 26, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Laura de Lima Xavier, Kristina Simonyan
Sep 28, 2020·Parkinsonism & Related Disorders·Charles H AdlerJohn N Caviness
Sep 29, 2020·Physical Medicine and Rehabilitation Clinics of North America·Jovauna CurreyBrandee L Waite

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