Comparison of botulinum toxin type A and aprotinin monotherapy with combination therapy in healing of burn wounds in an animal model.

Molecular Biology Reports
Ahmad Oryan, Esmat Alemzadeh

Abstract

Burns are one of the most common injuries that are complicated by many challenges including infection, severe inflammatory response, excessive expression of proteases, and scar formation. The aim of this study was to investigate the effect of botulinum toxin type A (BO) and aprotinin (AP) separately or in combination (BO-AP) in healing process. Four burn wounds were created in each rat and randomly filled with silver sulfadiazine (SSD), BO, AP and BO-AP. The rats were euthanized after 7, 14, and 28 days, and their harvested wound samples were evaluated by gross pathology, histopathology, gene expression, biochemical testing, and scanning electron microscopy. Both BO and AP significantly reduced expression of interleukin-1β (IL-1β) and transforming growth factor-β1 (TGF-β1) at the 7th post wounding day. Moreover, they inhibited scar formation by reducing the TGF-β1 level and increasing basic fibroblast growth factor (bFGF) at the 28th day. AP by decreasing protease production showed more effective role than BO in wound regeneration. AP increased tissue organization and maturation and improved cosmetic appearance of wounds, at 28 days. The best results gained when combination of BO and AP were used in healing of burn wounds. Trea...Continue Reading

References

Jul 23, 1998·Zentralblatt für Veterinärmedizin. Reihe A·A Oryan, S R Zaker
Jun 6, 2000·Plastic and Reconstructive Surgery·H G GassnerC C Otley
Jul 12, 2002·Medicinal Research Reviews·Claudiu T SupuranBrian W Clare
Sep 25, 2003·Plastic and Reconstructive Surgery·Holger G Gassner, David A Sherris
Feb 5, 2004·Clinics in Dermatology·K Roger Aoki
Dec 27, 2005·Burns : Journal of the International Society for Burn Injuries·M E van BaarE F van Beeck
Apr 19, 2006·International Wound Journal·Michel H E Hermans
Aug 12, 2006·Mayo Clinic Proceedings·Holger G GassnerDavid A Sherris
Jul 1, 1993·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·W StadelmannT Krizek
May 26, 2007·Anesthesiology·Christiane G FrickJ A Jeevendra Martyn
Sep 7, 2007·PLoS Medicine·Shahram AarabiGeoffrey C Gurtner
Nov 30, 2007·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·A OryanM N Soltani Rad
Jan 22, 2008·Journal of Cellular and Molecular Medicine·W Wagner, M Wehrmann
Jun 3, 2008·Burns : Journal of the International Society for Burn Injuries·Aliakbar Mohammadi, Hamed Ghoddusi Johari
May 13, 2009·Clinical and Experimental Otorhinolaryngology·Byung-Joo LeeHwal-Woong Kim
Feb 9, 2010·Journal of Dental Research·S Guo, L A Dipietro
Jun 12, 2010·Burns : Journal of the International Society for Burn Injuries·Ali Akbar MohammadiAhmad Reza Tavakkolian
Jul 16, 2010·Experimental Dermatology·Lars H EversPeter Mailänder
Feb 16, 2011·Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India·Fiona Procter
Feb 16, 2011·Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India·Arun Goel, Prabhat Shrivastava
Dec 17, 2011·Journal of Toxicology·Frank J LebedaMichael Adler
Feb 23, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhibo Xiao, Guofan Qu
Sep 7, 2012·Burns : Journal of the International Society for Burn Injuries·Ali Akbar MohammadiHamid Reza Tolide-ie
Oct 30, 2012·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Makram ZiadeJacques Yachouh
Apr 9, 2013·Burns : Journal of the International Society for Burn Injuries·Ali Akbar MohammadiIman Ahrari
Apr 9, 2013·Journal of Theoretical Biology·Le YangRamana M Pidaparti
Jun 14, 2013·International Journal of Inflammation·Jayme A FarinaRodrigo G Rosique
Feb 5, 2014·International Journal of Biological Macromolecules·Mohammad Reza TabandehAdel Mohammadalipour
Feb 15, 2014·Advances in Wound Care·Mohammadreza PakyariAziz Ghahary
Apr 2, 2014·Advances in Wound Care·Sara M McCarty, Steven L Percival
Apr 10, 2014·Disease Models & Mechanisms·Matthew Giannandrea, William C Parks
Dec 3, 2014·The International Journal of Biochemistry & Cell Biology·Fiona M Wood
May 18, 2016·Journal of Burn Care & Research : Official Publication of the American Burn Association·Colton B NielsonJohn G Wood
Sep 25, 2017·Advanced Drug Delivery Reviews·Yiwei WangPeter K M Maitz
Mar 24, 2018·Journal of Cosmetic Dermatology·RongTao HaoWei Ye
Jan 3, 2019·Plastic and Reconstructive Surgery·Amanda FanousSam J Daniel

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Methods Mentioned

BETA
biopsy
PCR

Software Mentioned

Digimizer
SPSS

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