Comparison of botulinum toxins A and B in the treatment of facial rhytides

Dermatologic Clinics
Neil S Sadick, Seth L Matarasso

Abstract

Facial rhytides of the upper one third of the face are common aesthetic concerns, and are caused principally by overactivity of the underlying facial musculature. Botulinum toxin, which acts by causing flaccid paralysis of facial mimetic muscles, has become a treatment of choice for the management of these hyperfunctional facial lines. Two antigenically distinct serotypes have been developed and are currently available for commercial use in the United States. There are major differences between the two toxins in terms of pharmacology and formulation that account for clinical differences, and precise interconversion is not well-established. Nevertheless, in these preliminary studies, Myobloc seems to have a faster onset of action and potentially a more even and smoother paralysis. The shorter duration of action of Myobloc seems to be dose-related. It is clear that both agents safely and effectively reduce dynamic facial rhytides. Based on individual efficacy, safety, diffusion pattern, onset, and duration, ultimately, with further trials and clinical experience, it is conceivable that each toxin will have its own set of indications.

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Citations

Dec 20, 2005·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Andrew Blitzer
Nov 26, 2013·Dermatologic Clinics·Andrew DorizasNeil S Sadick
Aug 23, 2011·The Journal of Hand Surgery·Brian A JanzKenneth R Means
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Jun 23, 2005·International Ophthalmology Clinics·Geva E Mannor
Dec 22, 2009·Expert Review of Neurotherapeutics·Frank J LebedaUma Mudunuri

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Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.

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