Comparison of breakfast and bedtime administration of insulin glargine in children and adolescents with Type 1 diabetes

Diabetes Research and Clinical Practice
Gülay KaragüzelIffet Bircan

Abstract

The purpose of this study was to evaluate the effect of administration time of insulin glargine (IG) on glycemic control in children and adolescents with Type 1 diabetes. A total of 31 children and adolescents (15 F and 16 M) with Type 1 diabetes on intensive therapy (bedtime NPH and premeal insulin aspart) were randomized to receive once-daily IG either at breakfast (breakfast group, n=15) or bedtime (bedtime group, n=16) while continuing insulin aspart premeals for 6 months. Blood glucose levels were measured fasting, preprandially and bedtime. Total daily insulin dose (TDD), body mass index (BMI), glycosylated hemoglobin (HbA(1c)), and frequency of hypoglycemia in the preceding 3 months were assessed at recruitment, third month and sixth month. The dose of IG, TDD, and fasting blood glucose levels were similar in both groups during the study period. The only significant difference in blood glucose levels between breakfast and bedtime groups was found for dinnertime at 6 months (135+/-26mg/dl versus 161+/-33mg/dl, respectively, p=0.035). In the breakfast group, the mean HbA(1c) level was significantly lower than that of baseline at month 6 (9.4+/-2.5% versus 8.0+/-0.9%, respectively, p=0.022), whereas there was no significant...Continue Reading

References

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Citations

Sep 1, 2008·Journal of Clinical Research in Pediatric Endocrinology·Damla Gökşen ŞimşekSükran Darcan
Mar 31, 2007·Seminars in Thoracic and Cardiovascular Surgery·Susan S Braithwaite
Jul 21, 2017·Journal of Paediatrics and Child Health·Dharrshinee SelvakumarUNKNOWN Paediatric Society of New Zealand Diabetes Clinical Network
Dec 20, 2007·Endocrine Research·Kathleen L Wyne, Pablo F Mora
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

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