Abstract
The purpose of this study was to evaluate the effect of administration time of insulin glargine (IG) on glycemic control in children and adolescents with Type 1 diabetes. A total of 31 children and adolescents (15 F and 16 M) with Type 1 diabetes on intensive therapy (bedtime NPH and premeal insulin aspart) were randomized to receive once-daily IG either at breakfast (breakfast group, n=15) or bedtime (bedtime group, n=16) while continuing insulin aspart premeals for 6 months. Blood glucose levels were measured fasting, preprandially and bedtime. Total daily insulin dose (TDD), body mass index (BMI), glycosylated hemoglobin (HbA(1c)), and frequency of hypoglycemia in the preceding 3 months were assessed at recruitment, third month and sixth month. The dose of IG, TDD, and fasting blood glucose levels were similar in both groups during the study period. The only significant difference in blood glucose levels between breakfast and bedtime groups was found for dinnertime at 6 months (135+/-26mg/dl versus 161+/-33mg/dl, respectively, p=0.035). In the breakfast group, the mean HbA(1c) level was significantly lower than that of baseline at month 6 (9.4+/-2.5% versus 8.0+/-0.9%, respectively, p=0.022), whereas there was no significant...Continue Reading
References
Jul 1, 1995·Archives of Disease in Childhood·T J ColeM A Preece
Jun 2, 2000·Diabetes Care·R E RatnerC A Wilson
Jun 27, 2000·Diabetes Care·T R PieberE Derobert
Nov 25, 2000·Diabetes Care·P RaskinT Mecca
Dec 16, 2000·Diabetes·M LeporeG B Bolli
Oct 27, 2001·Diabetes Care·E SchoberUNKNOWN Pediatric Study Group of Insulin Glargine
Mar 1, 2003·Diabetes Care·Nuala P MurphyDavid B Dunger
Mar 29, 2003·Diabetes Care·Giuseppe LeporeRoberto Trevisan
Apr 30, 2003·Diabetes Care·Paolo RossettiGeremia B Bolli
May 27, 2003·Diabetes Care·Andreas HamannUNKNOWN HOE901/4007 Study Group
Dec 6, 2003·Pediatric Diabetes·Anne JacksonAntoinette Moran
Jun 11, 2004·Pediatric Diabetes·Chin Yao TanBruce Buckingham
Jun 29, 2004·Diabetes Care·Elizabeth A DoyleWilliam V Tamborlane
Oct 23, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·F PorcellatiG B Bolli
Aug 30, 2005·Diabetes Research and Clinical Practice·E ColinoR Barrio
Citations
Sep 1, 2008·Journal of Clinical Research in Pediatric Endocrinology·Damla Gökşen ŞimşekSükran Darcan
Mar 31, 2007·Seminars in Thoracic and Cardiovascular Surgery·Susan S Braithwaite
Jul 21, 2017·Journal of Paediatrics and Child Health·Dharrshinee SelvakumarUNKNOWN Paediatric Society of New Zealand Diabetes Clinical Network
Dec 20, 2007·Endocrine Research·Kathleen L Wyne, Pablo F Mora
May 14, 2010·Postgraduate Medicine·Philip Zeitler
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity