PMID: 2096994Dec 1, 1990Paper

Comparison of breast cancer mucin (BCM) and CA 15-3 in human breast cancer

Breast Cancer Research and Treatment
M B GarciaJ H Thijssen

Abstract

The Breast Cancer Mucin (BCM) enzyme immunoassay utilizes two monoclonal antibodies (Mab), M85/34 and F36/22, for the identification of a mucin-like glycoprotein in serum of breast cancer patients. We have compared BCM with CA 15-3, another member of the human mammary epithelial antigen family. Serum BCM was evaluated in 151 and CA 15-3 in 134 patients with breast cancer, in 30 normal controls, in 9 pregnant women, and in 13 cancer patients (non-breast). Neither the normal controls nor the pregnant women had BCM levels greater than 25 U/ml. In contrast, 87 of 115 patients (75%) with metastatic breast cancer had BCM levels greater than 25 U/ml. All control persons had CA 15-3 levels less than 25 U/ml, but 2 out of 9 pregnant women (22%) had levels greater than 25 U/ml. Seventy-four out of 97 patients (76%) with metastatic breast cancer had CA 15-3 levels greater than 25 U/ml. A statistically significant correlation was found between BCM and CA 15-3 in the breast cancer patient group (r = 0.883, p less than 0.001, n = 134) and in the normal control group (r = 0.743, p less than 0.001, n = 30). BCM and CA 15.3 both showed no correlation with CEA in breast cancer patients (r = 0.060, n = 81; and r = 0.146, n = 78, respectively). BC...Continue Reading

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Citations

Jun 24, 1992·Journal of Immunological Methods·H Magdelénat
Mar 16, 1995·International Journal of Cancer. Journal International Du Cancer·S PalU Chattopadhyay
Mar 18, 2009·Medicinal Research Reviews·Shan JinBinghe Wang
Apr 22, 2000·Cancer Treatment Reviews·K L CheungJ F Robertson
Oct 6, 2010·Cancer Metastasis Reviews·Carlos A CastanedaEva M Ciruelos
Dec 17, 2002·The Journal of General and Applied Microbiology·Siu Wai ChiuMing Jie Chen
May 7, 2004·Nature·David C RubieDaniel J Frost
Mar 10, 2001·Nature·E G Nisbet, N H Sleep
Jun 9, 2001·Thyroid : Official Journal of the American Thyroid Association·P LaurbergS Andersen

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