PMID: 3756218Oct 1, 1986Paper

Comparison of brush border membrane glycoproteins and glycoenzymes in the proximal and distal rat small intestine

Biochimica Et Biophysica Acta
A MoritaY S Kim

Abstract

Brush border membranes isolated from the proximal and distal portions of the rat small intestine were examined to see whether qualitative differences exist in their glycoprotein constituents. After SDS-polyacrylamide gel electrophoresis distinct differences were observed, indicating that the protein and glycoprotein profiles of the distal intestine are less complex. A competitive radioassay of lectin receptors revealed that there are significantly more wheat germ agglutinin and succinylated wheat germ agglutinin receptors present on brush border membranes from proximal intestine as compared to distal intestine. However, binding of Ricinus communis agglutinin I to brush border membranes of distal intestine was 2-times higher than that of proximal intestine. These segmental differences were also reflected in the binding patterns of individual brush border membrane hydrolases to wheat germ agglutinin and R. communis agglutinin I. Carbohydrate analysis demonstrated that the overall sugar content of brush border membranes is higher in distal intestine, with more galactose and sialic acid residues. No difference was found in the content of N-acetylglucosamine between the two segments. When brush border membranes from both segments we...Continue Reading

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Citations

Oct 31, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·F GaborM Wirth
Dec 1, 1989·Gut·R Holmes, R W Lobley
Aug 31, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·YaShu YinHaiYang Hu
May 27, 2015·Nutrition Reviews·Devon KavanaughRita M Hickey
Dec 12, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·N Nanda NanthakumarW Allan Walker
May 31, 1989·Biochimica Et Biophysica Acta·C K OzakiW A Walker

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