Comparison of Ca2+ Handling for the Regulation of Vasoconstriction between Rat Coronary and Renal Arteries

Journal of Vascular Research
Lin LiuChun-Yu Deng

Abstract

Ca2+ plays an important role in the regulation of vasoconstriction. Ca2+ signaling is regulated by a number of Ca2+-handling proteins. However, whether differences in Ca2+ handling affect the regulation of vasoconstriction in different arteries remains elusive. To determine whether differences in Ca2+ handling affect the response to vasoconstrictors in different arteries. Arterial ring contraction was measured using a Multi Myograph System. Vascular smooth muscle cells (VSMCs) were digested with type 2 collagenase in DMEM, then intracellular calcium concentration was measured with the Ca2+ probe fluo-4/AM in the isolated cells. Calcium-related proteins were assayed by Western blotting. Phenylephrine did not induce -coronary arterial contraction. There were differences in -5-hydroxytryptamine, 9,11-dideoxy-11a,9a-epoxymethano-prostaglandin F2a, and endothelin 1-induced vasoconstriction in different solutions between coronary and renal arteries. Vasoconstrictions in the presence of Bay K8644 were stronger in coronary than in renal arteries. Store-operated calcium (SOC) channels could mediate Ca2+ influx in VSMCs of both groups. SOC channels did not participate in the contraction of coronary arteries. In addition, there were signi...Continue Reading

References

Feb 1, 1986·Cell Calcium·J W Putney
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·M J BerridgeM D Bootman
Jul 4, 2003·British Journal of Pharmacology·R FlemmingD J Beech
Jul 23, 2004·Physiological Reviews·Gary K OwensBrian R Wamhoff
Sep 19, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Jin ZhangDonald R Matteson
Feb 6, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Caroline A CobineKathleen D Keef
Feb 20, 2007·Circulation Research·Koichi HayashiTakao Saruta
Aug 28, 2007·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Young Min BaeSung Il Cho
Sep 19, 2007·British Journal of Pharmacology·F P LeungY Huang
May 15, 2008·Chemical Reviews·David E Nichols, Charles D Nichols
Apr 15, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marie PotierMohamed Trebak
Aug 4, 2009·Thrombosis Research·Vladimir Y Bogdanov, Bjarne Osterud
Dec 1, 2010·Acta Neurochirurgica. Supplement·Masayo KoideGeorge C Wellman
Oct 11, 2011·American Journal of Physiology. Heart and Circulatory Physiology·M Harold LaughlinDirk J Duncker
Oct 18, 2011·Basic & Clinical Pharmacology & Toxicology·Vladimir V MatchkovChristian Aalkjaer
Apr 21, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Victoria M Bolotina
Feb 5, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Biny K JosephSung W Rhee
Feb 6, 2013·European Journal of Pharmacology·Wai San CheangYu Huang
Jul 16, 2013·The FEBS Journal·Olga KudryavtsevaVladimir V Matchkov
Sep 26, 2013·Cardiovascular Diabetology·James T PearsonMikiyasu Shirai
Oct 12, 2013·Investigative Ophthalmology & Visual Science·Bahram KhoobehiJames Beach
Sep 15, 2014·Cell Calcium·María Fernández-VelascoAngélica Rueda
Dec 30, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Elise R Pfaltzgraff, David M Bader
Feb 12, 2015·Kidney International·Aleksander PrejbiszLars C Rump
Oct 6, 2015·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Bjarke JensenDane A Crossley
Dec 10, 2015·British Journal of Pharmacology·Stephen Ph AlexanderCgtp Collaborators
Dec 10, 2015·British Journal of Pharmacology·Stephen Ph AlexanderUNKNOWN CGTP Collaborators
Mar 24, 2017·Comprehensive Physiology·Nathan R TykockiWilliam F Jackson
Apr 14, 2017·Journal of Hypertension·Iago Méndez-LópezJ Fernando Padín

❮ Previous
Next ❯

Citations

Apr 2, 2021·Clinical and Experimental Pharmacology & Physiology·Run-Sheng JiangWei Wu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
Hua ZhouJie Song
Clinical and Experimental Pharmacology & Physiology
Hong YanChun-Yu Deng
American Journal of Physiology. Heart and Circulatory Physiology
W F Jackson
© 2021 Meta ULC. All rights reserved