Comparison of calcitonin versus calcitonin + resistance exercise as prophylaxis for osteoporosis in heart transplant recipients

Transplantation
Randy W BraithJuan M Aranda

Abstract

Rapid bone loss occurs early after heart transplantation. There is no standard therapeutic intervention to prevent osteoporosis in heart transplant recipients (HTR). The purpose of this study was to determine the effectiveness of a regimen combining the antiresorptive properties of nasal calcitonin with the osteogenic stimulus of resistance exercise. Eighteen candidates for heart transplantation were randomly assigned either to a group that received calcitonin and participated in 6 months of resistance exercise (n=10) or to a group that received only calcitonin (n=8). Calcitonin therapy (200 IU daily for 8 months) was initiated 48 hr after transplantation. Resistance exercise was initiated 2 months after transplantation. Bone mineral density (BMD) of the total body, femur neck, and lumbar vertebra (L2-3) were assessed before, and at 2 and 8 months after transplantation. Total body and femur neck BMD did not decrease (P>or=0.05) below pretransplantation values at 2 months after transplantation in either group. BMD of the lumbar spine was significantly (P<or=0.05) and comparably decreased at 2 months after transplantation in the calcitonin (-10.1+/-1.8%) and calcitonin + training groups (-12.9+/-2.7%). At 8 months after transplan...Continue Reading

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Citations

Oct 17, 2007·Heart Failure Reviews·Jonathan Myers
Mar 1, 1996·Journal of the American College of Cardiology·E L MayerK Robinson
Mar 21, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·R C CookA P Ignaszewski
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Jan 30, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Randy W BraithMaher A Baz
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Aug 24, 2016·American Journal of Physical Medicine & Rehabilitation·Jill NealeNicolette C Bishop
May 8, 2009·The Journal of Clinical Endocrinology and Metabolism·Peter R Ebeling

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