PMID: 8455503Jan 1, 1993Paper

Comparison of calculated and measured heterogeneity correction factors for 125I, 137Cs, and 192Ir brachytherapy sources near localized heterogeneities

Medical Physics
J F WilliamsonW R Lutz

Abstract

The influence of tissue and applicator heterogeneities on brachytherapy dose distributions is not well understood, despite widespread use of shielded applicators in intracavitary therapy. Heterogeneity correction factors (HCF) have been measured using a silicon diode detector arising from bounded heterogeneities consisting of lead, steel, titanium, silver, aluminum, and air cylinders near brachytherapy sources of 125I, 137Cs, and 192Ir. In addition, transverse-axis dose distributions for the three sources in homogeneous water were measured for distances of 0.2 to 16.0 cm. For each point of measurement, relative diode readings were simulated by a Monte Carlo photon transport code utilizing accurate models of the source internal structure, the experimental measure geometry and the source-strength calibration geometry. Comparison of measured and calculated HCF's reveals excellent agreement (1%-3% average) over a wide range of materials, diameters, and thicknesses. In addition, Monte Carlo simulation not only accurately reproduced the relative transverse-axis dose distributions in homogeneous medium, but was able to predict the variation of diode response with photon energy with an accuracy of 3% over the range of 30-662 keV. Our m...Continue Reading

Citations

Mar 15, 1996·International Journal of Radiation Oncology, Biology, Physics·A S MeigooniI J Kodner
Dec 1, 1996·International Journal of Radiation Oncology, Biology, Physics·J F Williamson
Jul 1, 1997·International Journal of Radiation Oncology, Biology, Physics·R K DasJ F Williamson
Jul 4, 1998·International Journal of Radiation Oncology, Biology, Physics·J F Williamson
May 10, 2002·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Ali S MeigooniKeith T Sowards
Aug 31, 2002·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Keith T Sowards, Ali S Meigooni
Dec 13, 2006·Medical Physics·Jeffrey F WilliamsonFritz A Lerma
Feb 7, 2007·Medical Physics·James DolanJeffrey F Williamson
Nov 26, 2010·Medical Physics·Dimitrios Lazos, Jeffrey F Williamson
Oct 27, 1998·International Journal of Radiation Oncology, Biology, Physics·J F DempseyJ F Williamson
Oct 14, 2011·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Nitai D MukhopadhyayAlexandr Malusek
May 22, 2008·Medical Physics·G IbbottJ F Williamson
Nov 4, 2008·Medical Physics·Bruce R ThomadsenAli S Meigooni
Jul 21, 2004·Medical Physics·Mark K MurphyMark H Phillips
Nov 26, 1998·Medical Physics·G M DaskalovJ F Williamson
Jun 3, 1998·Medical Physics·G M DaskalovJ F Williamson
Aug 1, 1997·Medical Physics·F BallesterF Lliso
Jan 19, 2002·Medical Physics·A S MeigooniK Sowards
Sep 30, 2000·Medical Physics·C C PopescuG S Ibbott
Jun 23, 2006·Physics in Medicine and Biology·Jeffrey F Williamson
Sep 1, 2007·Physics in Medicine and Biology·W C ToyeP N Johnston
Dec 1, 1993·Physics in Medicine and Biology·Z LiH Perera
Dec 1, 1995·Physics in Medicine and Biology·A s KirovY Zhu
May 1, 1995·Physics in Medicine and Biology·R K DasJ F Williamson
Dec 12, 1997·Physics in Medicine and Biology·A S Kirov, J F Williamson
Sep 2, 1998·Physics in Medicine and Biology·S N Rustgi
Apr 1, 1995·Physics in Medicine and Biology·B JohanssonT Holmström

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