Comparison of Candesartan versus Metoprolol for treatment of systemic hypertension after repaired aortic coarctation

The American Journal of Cardiology
Els MoltzerJolien W Roos-Hesselink

Abstract

Even after successful repair, hypertension is one of the main determinants of cardiovascular morbidity and mortality in patients with aortic coarctation (CoA). We compared the effect of candesartan (angiotensin II receptor blockade) and metoprolol (beta-adrenergic receptor blockade) on blood pressure, large artery stiffness, and neurohormonal status in hypertensive patients after repair of CoA. In the present open-label, crossover study, hypertensive patients after CoA repair were first randomly assigned to treatment with candesartan 8 mg or metoprolol 100 mg once per day. After 8 weeks of treatment with one of the drugs, the other treatment was given for 8 weeks. The treatment effects were assessed with 24-hour ambulatory blood pressure monitoring, measurement of large artery stiffness, and neurohormonal plasma levels at baseline and after 8 weeks of either treatment. Sixteen patients (mean age 37 +/- 12 years, 26 +/- 15 years after repair, 63% men) completed the study. The 24-hour mean arterial pressure at baseline was 97.7 +/- 6.2 mm Hg. Metoprolol (mean dose 163 +/- 50 mg/day) decreased the mean arterial pressure (7.0 +/- 4.2 and 4.1 +/- 3.6 mm Hg, respectively) more than did candesartan (mean dose 13 +/- 4 mg/day; p = 0.01...Continue Reading

References

Jan 1, 1990·Ultrasound in Medicine & Biology·A P HoeksR S Reneman
Jun 1, 1986·Ultrasound in Medicine & Biology·R S RenemanA P Hoeks
May 1, 1987·British Heart Journal·P PresbiteroA Brusca
Jul 1, 1983·The American Journal of Cardiology·R H BeekmanA P Rocchini
Feb 23, 1999·Heart·M Y Henein, D G Gibson
Mar 29, 2002·Lancet·Lorna SwanMichael A Gatzoulis
Sep 26, 2003·Journal of Cardiovascular Pharmacology·Anton H van den MeirackerFrans Boomsma
Mar 20, 2004·Expert Review of Cardiovascular Therapy·Azra Mahmud, John Feely
May 24, 2005·International Journal of Cardiology·Joris W J Vriend, Barbara J M Mulder
Jun 15, 2007·Journal of Hypertension·Francesco U S Mattace-RasoJacqueline C M Witteman

❮ Previous
Next ❯

Citations

Nov 19, 2013·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Ana Sofia CorreiaMaria Júlia Maciel
Feb 4, 2014·Current Hypertension Reports·John O'Sullivan
Jul 1, 2014·Future Cardiology·Emma Roche-Kelly, Catherine Nelson-Piercy
May 20, 2014·International Journal of Cardiology·Andrew J S Coats, John M Cruickshank
Oct 17, 2015·Cardiology Clinics·Lan Nguyen, Stephen C Cook
Oct 9, 2012·International Journal of Cardiology·Carla CanniffeDavid Celermajer
Apr 17, 2016·British Journal of Clinical Pharmacology·Charles KhouriMatthieu Roustit
May 19, 2017·World Journal for Pediatric & Congenital Heart Surgery·Peter P Roeleveld, Eline G Zwijsen
Jan 21, 2016·Circulation·Karen K StoutUNKNOWN American Heart Association Council on Clinical Cardiology, Council on Functional Genomics and Translational Biology, and Cou
Oct 19, 2017·Pediatric Cardiology·Trisha V VigneswaranMarietta Charakida
Oct 26, 2018·Hypertension·Robert M CareyUNKNOWN American Heart Association Professional/Public Education and Publications Committee of the Council on Hypertension; Council

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Aortic Coarctation

Aortic coarctation is a congenital condition characterized by narrowing of the aorta. Discover the latest research on this disease here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.