Comparison of cartilage histopathology assessment systems on human knee joints at all stages of osteoarthritis development.

Osteoarthritis and Cartilage
C PauliM K Lotz

Abstract

To compare the MANKIN and OARSI cartilage histopathology assessment systems using human articular cartilage from a large number of donors across the adult age spectrum representing all levels of cartilage degradation. Human knees (n=125 from 65 donors; age range 23-92) were obtained from tissue banks. All cartilage surfaces were macroscopically graded. Osteochondral slabs representing the entire central regions of both femoral condyles, tibial plateaus, and the patella were processed for histology and Safranin O - Fast Green staining. Slides representing normal, aged, and osteoarthritis (OA) tissue were scanned and electronic images were scored online by five observers. Statistical analysis was performed for inter- and intra-observer variability, reproducibility and reliability. The inter-observer variability among five observers for the MANKIN system showed a similar good Intra-class correlation coefficient (ICC>0.81) as for the OARSI system (ICC>0.78). Repeat scoring by three of the five readers showed very good agreement (ICC>0.94). Both systems showed a high reproducibility among four of the five readers as indicated by the Spearman's rho value. For the MANKIN system, the surface represented by lesion depth was the paramete...Continue Reading

References

Jan 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J A van der SluijsJ Drukker
Apr 20, 1999·Tissue Engineering·S W O'DriscollD E Beaton
Jun 12, 1999·Annals of the Rheumatic Diseases·K OstergaardD M Salter
Jun 29, 2001·Tissue Engineering·S W O'DriscollJ S Fitzsimmons
May 25, 2002·Osteoarthritis and Cartilage·J L HyllestedK Ostergaard
Jan 30, 2003·Osteoarthritis and Cartilage·K GelseT Aigner
Sep 24, 2004·Rheumatology·D T FelsonM P Lavalley
Oct 26, 2005·Osteoarthritis and Cartilage·K P H PritzkerW B van den Berg
Jan 31, 2006·Osteoarthritis and Cartilage·U Irlenbusch, Th Schäller
Jul 25, 2006·Osteoarthritis and Cartilage·C M ThomasM Sharif
Feb 27, 2007·Osteoarthritis and Cartilage·R D Altman, G E Gold
Jul 7, 2007·Journal of Biopharmaceutical Statistics·J Martin Bland, Douglas G Altman
Oct 31, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S Farshid Moussavi-HaramiThomas D Brown
Oct 1, 2010·Osteoarthritis and Cartilage·T AignerV B Kraus

❮ Previous
Next ❯

Citations

May 13, 1999·Progress in Histochemistry and Cytochemistry·K Ostergaard, D M Salter
Jun 1, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Patricia Ann KramerPeter A Simkin
Aug 8, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Wenzel WaldsteinFriedrich Boettner
Aug 12, 2014·Osteoarthritis and Cartilage·H J NieminenS A Hacking
Apr 19, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Daisuke HatsushikaIchiro Sekiya
Mar 20, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Makiko OkunoIchiro Sekiya
Oct 12, 2013·Journal of Anatomy·E J Hargrave-ThomasN D Broom
Oct 19, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Jonathan T KaplanDavid M Pierce
Jun 23, 2016·Acta Radiologica·Ali ÖzgenZeynep Fırat
Oct 19, 2017·Journal of Orthopaedic Trauma·K Aaron ShawStephen A Parada
Jun 28, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Meike W A KleuskensKeita Ito
Jun 24, 2020·BMC Complementary Medicine and Therapies·Juntao ZhangMan Shang
Jul 8, 2016·Science Translational Medicine·Katja M HeinemeierMichael Kjaer
Feb 19, 2020·BMC Research Notes·Bastian L GruberMartin Flück
Aug 23, 2020·International Journal of Molecular Sciences·Elisa BelluzziMarta Favero
Jan 21, 2019·Osteoarthritis and Cartilage·F MaierD M Pierce
Mar 23, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yunfei LiMohammed Sharif
Apr 14, 2021·Osteoarthritis and Cartilage·M WuR G P Lopata
Apr 9, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Melissa FranklinBeth A Winkelstein
Jan 18, 2019·Osteoarthritis and Cartilage·Y HeA C Bay-Jensen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.