PMID: 9006721Nov 1, 1996Paper

Comparison of cationic myocardial perfusion agents: characteristics of accumulation in cultured smooth muscle cells

Annals of Nuclear Medicine
K NakamuraA Kubo

Abstract

The uptake and washout kinetics of two cationic lipophilic 99mTc-labeled myocardial perfusion agents, 99mTc-methoxyisobutylisonitrile (99mTc-MIBI) 99mTc-1,2-bis[bis-2-ethoxyethyl)-phosphino]ethane (99mTc-Tetrofosmin), were studied in cultured smooth muscle cells and compared to the conventional myocardial perfusion agent, 201Tl. Both 99mTc-MIBI and 99mTc-Tetrofosmin had a 4-fold greater uptake then 201Tl, and they were washed out of cells through similar kinetics which had slower rates than 201Tl. Incubation with metabolism inhibitors had a modest influence on the uptake of these two 99mTc-labeled agents, although their extent and inhibited sites were slightly different. Ion transport inhibitors did not affect the uptake of 99mTc-MIBI, although the 99mTc-Tetrofosmin uptake was slightly inhibited when the Ca2+ channel was blocked. Our studies indicate that 99mTc-MIBI and 99mTc-Tetrofosmin were taken up by smooth muscle cells in similar pharmacokinetic patterns, but their accumulation reflected a different meaning for cell viability.

References

Feb 1, 1992·International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology·J F KronaugeD Piwnica-Worms
Jan 1, 1993·European Journal of Nuclear Medicine·P CraneC Orlandi
Jan 1, 1994·Seminars in Nuclear Medicine·C W SutterR C Stadalnik
Jan 1, 1993·Cancer Chemotherapy and Pharmacology·D Piwnica-WormsJ F Kronauge
Jul 1, 1995·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·E A PlattsJ D Kelly

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Citations

Jun 16, 2004·Annals of Nuclear Medicine·Mitsutaka Fukumoto
Aug 30, 2008·Annals of Nuclear Medicine·David R OkadaGerald Johnson
Mar 22, 2005·Cancer Biotherapy & Radiopharmaceuticals·Bruno FattoriGiuliano Mariani
Sep 30, 2000·Tecnologica. MAP Supplement
Dec 14, 1999·Clinical Nuclear Medicine·M P StokkelP P van Rijk

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