Comparison of CD4 and CD8 lymphocyte counts in HIV-negative pulmonary TB patients with those in normal blood donors and the effect of antitubercular treatment: hospital-based flow cytometric study

Cytometry. Part B, Clinical Cytometry
S S UppalP S Dhot

Abstract

This study was designed to flow cytometrically determine baseline and sequential values of CD4 and CD8 lymphocyte subsets in patients without the human immunodeficiency virus and with pulmonary tuberculosis (TB) and to correlate these values with those obtained from normal male blood donors and with the radiologic extent of disease and response to therapy. We studied 39 male patients without the human immunodeficiency virus and with sputum positive for pulmonary TB who had been admitted to Military Hospital (Cardiothoracic Center) in Pune, India. Clinical, laboratory, and radiologic evaluations of these patients were done. Hematologic parameters were assessed by an automated hematology cell counter (AcT*Diff, Coulter), and T-cell subsets (CD4 and CD8) were determined flow cytometrically (EPICS-XL, Coulter). CD4 counts and percentages of CD4 were significantly lower, but CD8 values were normal, in patients with pulmonary TB when compared with values obtained in normal blood donors. The CD4/CD8 ratio was significantly lower in patients with TB. The CD4 counts normalized with antitubercular treatment. The radiologic extent of disease did not correlate well with the immune parameters studied. TB is a reversible cause of CD4 lymphoc...Continue Reading

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Citations

Aug 3, 2006·Mediators of Inflammation·Figen DeveciFulya Ilhan
Aug 4, 2011·European Journal of Medical Research·Abdulkarim Al-AskaN A Al Anazi
Jan 12, 2013·PloS One·Nidhi KapoorPappachan E Kolattukudy
Jun 26, 2012·The Journal of Infection·Najwa A MhmoudWendy W J van de Sande
Apr 30, 2008·International Immunopharmacology·Lyudmila G NikolaevaGalyna A Kutsyna
Feb 16, 2006·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·József BocsiAttila Tárnok
Apr 9, 2019·International Journal of Immunopathology and Pharmacology·Elisabetta VenturiniLuisa Galli
Apr 13, 2010·Immunological Investigations·Jesús HernandezAdriana Garibay-Escobar
Aug 19, 2006·The Journal of Biological Chemistry·Frederique RufStuart C Sealfon
Jul 3, 2020·Research and Reports in Tropical Medicine·Joseph Baruch BalukuWinceslaus Katagira

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