Comparison of Centor and McIsaac scores in primary care: a meta-analysis over multiple thresholds.

The British Journal of General Practice : the Journal of the Royal College of General Practitioners
Brian H WillisMohammed Baragilly

Abstract

Centor and McIsaac scores are both used to diagnose group A beta-haemolytic streptococcus (GABHS) infection, but have not been compared through meta-analysis. To compare the performance of Centor and McIsaac scores at diagnosing patients with GABHS presenting to primary care with pharyngitis. A meta-analysis of diagnostic test accuracy studies conducted in primary care was performed using a novel model that incorporates data at multiple thresholds. MEDLINE, EMBASE, and PsycINFO were searched for studies published between January 1980 and February 2019. Included studies were: cross-sectional; recruited patients with sore throats from primary care; used the Centor or McIsaac score; had GABHS infection as the target diagnosis; used throat swab culture as the reference standard; and reported 2 × 2 tables across multiple thresholds. Selection and data extraction were conducted by two independent reviewers. QUADAS-2 was used to assess study quality. Summary receiver operating characteristic (SROC) curves were synthesised. Calibration curves were used to assess the transferability of results into practice. Ten studies using the Centor score and eight using the McIsaac score were included. The prevalence of GABHS ranged between 4% and ...Continue Reading

References

Jan 1, 1981·Medical Decision Making : an International Journal of the Society for Medical Decision Making·R M CentorK Link
Mar 1, 1993·Archives of Otolaryngology--head & Neck Surgery·H SeppäläP Huovinen
Sep 25, 2001·Statistics in Medicine·C M Rutter, C A Gatsonis
Mar 13, 2003·Mayo Clinic Proceedings·Thomas G McGinnJuan P Wisnivesky
Apr 12, 2003·Journal of Clinical Microbiology·Claudia M BrandtRudolf Lütticken
Jul 30, 2005·Journal of General Internal Medicine·Steven J AtlasMichael J Barry
Sep 20, 2005·Journal of Clinical Epidemiology·Johannes B ReitsmaAeilko H Zwinderman
Oct 29, 2005·The Lancet Infectious Diseases·Jonathan R CarapetisMartin Weber
Nov 18, 2008·Journal of Clinical Epidemiology·Miriam BrazzelliPeter A G Sandercock
Mar 6, 2012·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·G Regueras De LorenzoM Nicieza García
May 9, 2012·Archives of Internal Medicine·Andrew M FineKenneth D Mandl
Dec 6, 2012·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Paul LittleUNKNOWN PRISM investigators
Jun 21, 2013·Journal of Chemotherapy·Zuleyha AlperNazan Gonul Bilgel
Jul 13, 2013·BMC Infectious Diseases·Eileen M DunneAndrew C Steer
Jan 23, 2014·Journal of Clinical Epidemiology·Brian H Willis, Christopher J Hyde
Dec 7, 2014·Journal of Clinical Epidemiology·Brian H Willis, Christopher J Hyde
Mar 27, 2015·Family Practice·Selcuk MistikFahri A Onuk
Jan 13, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jochen P WindfuhrReinhard Berner
Aug 16, 2016·BMC Medical Research Methodology·Susanne SteinhauserGerta Rücker
Apr 22, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E StefaniukW Hryniewicz
Oct 3, 2018·Journal of Clinical Epidemiology·Brian H WillisMohammed Baragilly
Jun 4, 2019·BMC Family Practice·Kasper Basse ReinholdtTejs Ehlers Klug
Oct 24, 2019·The Cochrane Database of Systematic Reviews·Miranda CumpstonJames Thomas

❮ Previous
Next ❯

Citations

Mar 29, 2020·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Hajira Dambha-MillerPaul Little
May 30, 2020·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Brian H WillisMohammed Baragilly
Nov 1, 2020·Antibiotics·Sabiha EssackAdrian Shephard

❮ Previous
Next ❯

Software Mentioned

Google Scholar
Centor
QUADAS
Quality Assessment of Diagnostic Accuracy Studies ( QUADAS - 2 )
R package

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.