Comparison of cerebral oxygen saturation in premature infants by near-infrared spatially resolved spectroscopy: observations on probe-dependent bias

Journal of Biomedical Optics
Line C SorensenG Greisen

Abstract

Spatially resolved spectroscopy (SRS) allows the estimation of absolute tissue oxygen saturation, the ratio of oxygenated to total hemoglobin concentration, which may facilitate the comparison of results among patients. Eighty-two premature infants were included over two years. The cerebral tissue oxygenation index (c-TOI) was measured using NIRO 300 (Hamamatsu Photonics KK). c-TOI was measured at several positions in each infant. c-TOI varied over time, increasing in the first third and decreasing in the last third of the study period (p<10(-6)). Two probes were used in the study, and a highly significant difference was found between these (p<10(-6)). The mean difference was 8.5% (95%CI 5.4 to 11.6%). After correction for this difference, there was no variation over time. A conclusive explanation for the bias could not be identified. Since the study groups were well distributed, the bias had no influence on the results of our clinical study. We investigated an unexpected but highly significant probe-dependent bias in c-TOI with no conclusive explanation. Hence, comparisons of absolute TOI between groups of patients and among studies should be regarded with caution. A better strategy to detect potential instrumental problems wi...Continue Reading

References

Oct 13, 2001·Developmental Neuroscience·G Greisen, K Børch
Feb 13, 2003·Advances in Experimental Medicine and Biology·Gunnar NaulaersHugo Devlieger
Feb 13, 2008·Applied Optics·A KienleH van den Bergh

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Citations

Jun 7, 2011·Journal of Biomedical Optics·Mirjam PocivalnikBerndt Urlesberger
Dec 1, 2009·Clinics in Perinatology·Martin Wolf, Gorm Greisen
May 3, 2015·Seminars in Fetal & Neonatal Medicine·Beena G SoodJosef Cortez
Sep 21, 2015·The Journal of Pediatrics·Mmoloki KenosiEugene M Dempsey
Nov 11, 2014·Developmental Medicine and Child Neurology·Elise A VerhagenArend F Bos
Feb 23, 2013·Neonatology·Munira AlmaazmiHans Fuchs
Jun 28, 2011·Neonatology·Nina TaxBerndt Urlesberger
Feb 9, 2021·Frontiers in Pediatrics·Leeann R PavlekOmid Fathi

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