Comparison of changes in blood pressure and dipsogenic responsiveness to angiotensin II in male and female rats chronically exposed to cold

Physiology & Behavior
Z SunJ R Cade

Abstract

In most forms of experimentally induced hypertension in rats, females develop a less severe form of the disease than males. The objective of the present study was to compare the two genders with respect to the development of cold-induced hypertension. The results of the study indicate that both males and females develop comparable elevations of blood pressure and at approximately the same rate. Thus, the blood pressures of both groups increased significantly within 2 weeks of exposure to cold and reached similar maximal levels by the seventh week. The dipsogenic responsiveness of both groups of cold-exposed rats to acute administration of the peptide hormone, angiotensin II (AngII), was increased to approximately the same extent above that of warm-adapted counterparts, suggesting an increase in the responsiveness to AngII in the brain. To assess this possibility, the induction of the oncogene, cFos, was studied in brain following IV infusion of AngII (333 ng/kg/min). Fos-like immunoreactivity (FLI) was greater (p < 0.01) in subfornical organ, supraoptic and paraventricular hypothalamic nuclei of both cold-exposed groups compared to warm-adapted controls. Thus, both male and female rats have similar elevations of blood pressure ...Continue Reading

References

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Citations

Mar 12, 1999·Physiology & Behavior·Z SunM J Fregly
Oct 14, 2016·Human Gene Therapy·Peter Gin-Fu Chen, Zhongjie Sun
Jun 3, 2017·Hormones and Behavior·Jessica SantolloDerek Daniels
Jul 18, 2017·Experimental Physiology·Jessica Santollo
Oct 23, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Zhongjie SunJ Robert Cade
Dec 31, 2005·Journal of Applied Physiology·Gin-Fu Chen, Zhongjie Sun
Feb 5, 2002·American Journal of Hypertension·Zhongjie SunCerinda Morales
Nov 25, 2020·Physiology & Behavior·Jessica Santollo, Andrea A Edwards

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