Comparison of changes over time in leukocyte counts in Yucatan minipigs irradiated with simulated solar particle event-like radiation

Life Sciences in Space Research
Jenine K SanzariAnn R Kennedy

Abstract

During a major solar particle event (SPE), astronauts in space are at risk of exposure to an increased dose of proton radiation. The whole body distribution of the absorbed SPE proton dose is inhomogeneous, and such an inhomogeneous SPE proton dose can be simulated by electron radiation. Using Yucatan minipigs as an animal model, we compared the time courses of leukocyte count changes after exposure to proton simulated SPE (pSPE) radiation or electron simulated SPE (eSPE) radiation. The results demonstrated that the time required after irradiation to reach the lowest leukocyte counts was generally comparable between the pSPE and eSPE radiation exposures. However, the leukocyte count often recovered faster after electron irradiation compared to proton irradiation at the corresponding doses. In addition, the radiation dose required to achieve comparable magnitudes of leukocyte count decrease was higher in the eSPE animals than for the pSPE animals. In conclusion, based on the magnitude of the decrease and the time required to reach the lowest leukocyte counts after irradiation, the pSPE radiation was more effective than the eSPE radiation in reducing the peripheral leukocyte counts. Lymphocytes appeared to be the most sensitive t...Continue Reading

References

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Jan 20, 2007·Die Naturwissenschaften·Christine E Hellweg, Christa Baumstark-Khan
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May 31, 2013·The Onderstepoort Journal of Veterinary Research·Tingting CuiSanjie Cao

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Citations

Aug 1, 2018·International Journal of Molecular Sciences·Christine E HellwegChrista Baumstark-Khan
Mar 10, 2017·Frontiers in Immunology·Rodrigo Fernandez-GonzaloMarjan Moreels
Jan 10, 2021·Scientific Reports·M H YashavarddhanSandeep Kumar Shukla

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