Comparison of chemotherapeutic treatment outcomes of advanced extrapulmonary neuroendocrine carcinomas and advanced small-cell lung carcinoma

Neuroendocrinology
T TerashimaTakuji Okusaka

Abstract

The chemotherapy for small-cell lung carcinoma (SCLC) has been adopted for advanced extrapulmonary neuroendocrine carcinomas (EP-NECs). The aim of this study was to clarify the efficacy of standard SCLC regimens when used to treat EP-NECs and to compare the outcome with that for SCLC. We reviewed the medical records of 136 patients (41 with EP-NEC and 95 with SCLC) who were treated using a platinum-containing regimen for advanced disease between January 2000 and October 2008 at our hospital. The primary site of the EP-NEC was the gastrointestinal tract in 18 patients (GI tract group); the liver, biliary tract or pancreas in 16 patients (HBP group), and other sites in 7 patients ('others' group). The response rate in the SCLC patients was 77.8%, and the response rate in the EP-NEC patients was 30.8% (37.5% in the GI tract group, 12.5% in the HBP group, and 57.1% in the 'others' group). The median survival time for the SCLC patients was 13.6 months, while that for the EP-NEC patients was 9.2 months (14.9 months in the GI tract group, 7.8 months in the HBP group, and 8.9 months in the 'others' group). A multivariate analysis demonstrated that a poor performance status, liver involvement, and the treatment regimen were independent ...Continue Reading

References

May 1, 1997·Cancer·E GalanisR V Lloyd
Jul 1, 1997·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E T JansonK Oberg
Feb 16, 1999·Journal of Surgical Oncology·T L MoskalH R Nava
Feb 24, 1999·Human Pathology·K TakuboK Sasajima
Jan 11, 2002·The New England Journal of Medicine·Kazumasa NodaUNKNOWN Japan Clinical Oncology Group
Mar 19, 2004·Endocrine-related Cancer·M T BarakatS R Bloom
May 20, 2004·British Journal of Cancer·B BrennerD P Kelsen
Jul 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Baruch BrennerDavid P Kelsen
Jul 3, 2004·Japanese Journal of Clinical Oncology·Jung Han KimKeunchil Park
Dec 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maria A KouvarakiJames C Yao
May 2, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nasser HannaAlan Sandler
Sep 13, 2006·Virchows Archiv : an International Journal of Pathology·G RindiUNKNOWN European Neuroendocrine Tumor Society (ENETS)
Sep 26, 2006·Cancer·Kamal HaiderShahid Ahmed
Feb 22, 2007·Neuroendocrinology·Ola NilssonUNKNOWN European Neuroendocrine Tumor Society
Mar 27, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Günter Klöppel
Jul 27, 2007·Acta Oncologica·Sung Sook LeeYoon-Koo Kang
Aug 4, 2007·Virchows Archiv : an International Journal of Pathology·G RindiB Wiedenmann
Oct 18, 2007·Neuroendocrinology·Hakan AhlmanUNKNOWN Frascati Consensus Conference participants
Jan 23, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R BettiniM Falconi
Jun 21, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James C YaoDouglas B Evans
Dec 11, 2008·Cancer Treatment Reviews·Annemiek M E WalenkampDirk T Sleijfer

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Citations

Feb 9, 2016·Diagnostics·Emma Elizabeth IlettUlrich Knigge
Aug 16, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jarushka NaidooPaula Calvert
Apr 29, 2014·Cancer·Halfdan SorbyeJames C Yao
Jan 19, 2017·International Journal of Molecular Sciences·Akihiro OhmotoShinichi Yachida
Jun 15, 2016·World Journal of Clinical Oncology·Inderpaul Singh SehgalNavneet Singh
Jan 11, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Jooae ChoeNikhil Ramaiya
Apr 30, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Susumu HijiokaNobumasa Mizuno
Jan 20, 2020·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Gavin S JonesTricia M McKeever
Mar 18, 2021·Surgical Case Reports·Tatsuki IshikawaYohei Hosokawa
Apr 29, 2019·Neuroendocrinology·María Rodríguez-RemírezArancha Cebrián

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