Comparison of chromogranin A, insulin-like growth factor 1 and prostate-specific antigen serum markers in prostate adenocarcinoma and benign prostatic hyperplasia

Urologia Internationalis
A SciarraFranco Di Silverio

Abstract

To compare serum chromogranin A (CgA) and insulin-like growth factor 1 (IGF-1) with the classical prostate-specific antigen (PSA) marker in clinically localized prostate adenocarcinomas. This is a prospective single-center study that included 64 consecutive men with newly diagnosed clinically localized prostate adenocarcinoma and 20 consecutive men with histologically confirmed benign prostatic hyperplasia (BPH). A blood sample for the determination of serum total PSA, CgA and IGF-1 levels (RIA) was obtained from all cases. Analysis of variance was performed to evaluate their variations according to disease and the pathological characteristics of prostate adenocarcinoma. Only serum PSA levels (p < 0.0001) and not IGF-1 (p = 0.5475) or CgA (p = 0.5043) were significantly higher in the prostate cancer (PCa) group as compared to the BPH group. A significant variance between BPH and PCa divided on the basis of pT stage was found for PSA levels (p < 0.0001) but not for CgA (p = 0.0869) and IGF-1 (p = 0.6883) levels. Dividing PCa on the basis of Gleason score, a significant variance was found for CgA (p = 0.0100) and for PSA (p < 0.001), but not for IGF-1 (p = 0.6895) levels. In our population the quantification of PSA and CgA serum ...Continue Reading

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Citations

Jul 1, 2009·Expert Opinion on Medical Diagnostics·Carlos H MartínezJoseph Chin
Aug 26, 2011·Differentiation; Research in Biological Diversity·Ian D McLarenWade Bushman
May 1, 2015·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Livia L CorreaMonica R Gadelha
Mar 10, 2011·International Braz J Urol : Official Journal of the Brazilian Society of Urology·L CindoloC Cillo

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