PMID: 8609451Feb 1, 1996Paper

Comparison of chromosomal damage induced by X-rays and Ar ions with an LET of 1840 keV/micrometer in G1 V79 cells

International Journal of Radiation Biology
S RitterG Kraft

Abstract

Synchronous V79 Chinese hamster cells were exposed in G1 to either X-rays or 4.6 MeV/u Ar-ions (LET = 1840 keV/micrometer) and the induction of chromosomal damage was measured at five sampling times ranging from 14 to 30 h after treatment. To distinguish between cells in the first and second post-irradiation cycle the fluorescence-plus-Giemsa technique was applied. The experiment showed that the time-course of the appearance of damaged cells was markedly influenced by radiation-induced cell cycle delays and depended on both radiation quality and dose. The yield of aberrant metaphases and the number of aberrations per metaphase was found to increase with sampling time, but this increase was more pronounced for Ar ions. These differences in yield-time profiles of X-ray and Ar ion induced chromosomal damage are particularly important for an accurate determination of the RBE for particles. Our data clearly indicate that meaningful RBEs can only be obtained if chromosomal damage is analysed at several post-irradiation sampling times and the complete time-course of the expression of chromosomal damage is taken into account. Besides these quantitative differences, differences in the spectrum of chromosomal lesions were observed for X-...Continue Reading

References

Apr 30, 1975·Journal of Medical Entomology·R J Barker, W F Anderson
Nov 1, 1990·International Journal of Radiation Biology·K SuzukiM Watanabe
May 1, 1987·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·E AufderheideG Kraft
Jan 1, 1994·International Journal of Radiation Biology·K M Prise
Aug 1, 1993·International Journal of Radiation Biology·K J Weber, M Flentje

❮ Previous
Next ❯

Citations

Aug 13, 2011·Radiation Protection Dosimetry·Mónica PujolJoan-Francesc Barquinero
Jun 21, 2005·International Journal of Radiation Biology·E Gudowska-NowakS Ritter
Dec 29, 2005·Statistics in Medicine·Yin Bun Cheung, K F Lam
Nov 10, 2009·International Journal of Radiation Biology·Daniela BeckerClaudia Fournier
Jul 31, 2010·International Journal of Radiation Biology·Marta Deperas-KaminskaAndrzej Wojcik
Jun 7, 2005·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·R LeeS Ritter
Apr 20, 2007·Radiation and Environmental Biophysics·Z Z WangB Liu
Aug 12, 2009·Radiation and Environmental Biophysics·Anna Ochab-MarcinekSylvia Ritter
Nov 8, 2005·Radiation and Environmental Biophysics·A HeimersW Hoffmann
Aug 19, 2017·Radiation Research·Alice SollazzoAndrzej Wojcik
Sep 16, 2016·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Alice SollazzoAndrzej Wojcik
Jun 10, 2003·Journal of Radiation Research·Tetsuya KawataFrancis A Cucinotta
Jan 10, 2003·Journal of Radiation Research·Manami Monobe, Koichi Ando
Apr 15, 2008·International Journal of Radiation Oncology, Biology, Physics·Kerstin BorgmannEkkehard Dikomey
Sep 7, 2001·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·E NasonovaG Kraft

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)
E NasonovaG Kraft
Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)
Sylvia RitterG Kraft
Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)
E NasonovaG Kraft
© 2021 Meta ULC. All rights reserved