Comparison of chronic kidney disease and risk for presenting with painless versus nonpainless acute myocardial infarction

The American Journal of Cardiology
Min Goo LeeJung Chaee Kang

Abstract

Chronic kidney disease increases the risk for developing ischemic heart disease, but it has not been well known whether it also affects the manifestation of painless acute myocardial infarction (AMI), which has important clinical implications. The aim of this study was to identify whether chronic kidney disease is associated with the presentation of painless AMI. A total of 2,656 consecutively hospitalized patients with AMI from January 2008 to February 2012 were enrolled. Estimated glomerular filtration rate (eGFR) was calculated using calibrated serum creatinine and the abbreviated Modification of Diet in Renal Disease (MDRD) equation. Patient clinical characteristics, angiographic findings, and the use of medications were reviewed. Multivariate logistic regression analysis was used to examine the association of reduced eGFR and presentation with painless AMI. A total of 2,176 adults with painful AMI and 480 adults with painless AMI were studied, and baseline eGFR was calculated. Mean eGFR was lower in subjects with painless AMI compared to those with painful AMI. Compared to an eGFR >90 ml/min/1.73 m(2), a strong, graded, independent association was observed between reduced eGFR and presentation with painless AMI, with adjus...Continue Reading

Citations

May 15, 1991·The American Journal of Cardiology·A LangerP W Armstrong
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Dec 17, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·D J Burn, D Bates
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Aug 16, 2006·Annals of Internal Medicine·Andrew S LeveyChronic Kidney Disease Epidemiology Collaboration
Nov 27, 2007·Journal of the American College of Cardiology·Kristian ThygesenJoint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction
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Related Concepts

Autonomic Nervous System Disorders
Ischemia
Kidney Function Tests
Coronary Artery Disease
Chronic Kidney Insufficiency
Epidermal Growth Factor Receptor Activity
Pupil Disorders
Bundle-Branch Block
Myocardial Infarction
Myocardial Ischemia

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