Comparison of circulating levels of interleukin-6 and tumor necrosis factor-alpha in hypertrophic cardiomyopathy and in idiopathic dilated cardiomyopathy

The American Journal of Cardiology
Márta HögyeKrisztina Buzás

Abstract

It is known from the literature that the circulating levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) are elevated in heart failure and idiopathic dilated cardiomyopathy (IDC). Few convincing data are available on the production of cytokines in hypertrophic cardiomyopathy (HC). The levels of circulating IL-6, the soluble form of the IL-6 receptor (sIL-6R), and TNF-alpha in 19 patients with HC, 31 patients with IDC, and 20 healthy subjects (control group) were examined and compared with their clinical parameters. The levels of TNF-alpha and circulating IL-6 proved to be elevated in the sera of patients with IDC. In contrast, the level of TNF-alpha was not elevated in HC, although the levels of IL-6 and sIL-6R were significantly higher than those in the sera of patients with IDC. Although elevated levels of IL-6 may correlate with the extent of left ventricular dysfunction in IDC, the markedly elevated IL-6 levels did not correlate with left ventricular function in HC. The markedly elevated TNF-alpha levels in IDC were associated with the elevated IL-6 levels, probably because of an inflammatory process and/or heart failure. In contrast, in HC, in which the New York Heart Association functional class was...Continue Reading

References

Oct 1, 1987·European Journal of Immunology·L A AardenP M Lansdorp
Dec 1, 1994·British Heart Journal·A MatsumoriS Sasayama
Jul 1, 1997·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·K C Wollert, K R Chien
Feb 15, 2001·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Y MándiM Csanády

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Citations

Sep 16, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tamayo MuraseKohzo Nagata
Sep 7, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Daniela CardinaleMaria T Sandri
Apr 22, 2010·Heart Failure Reviews·Arash HaghikiaDenise Hilfiker-Kleiner
Apr 6, 2006·The Journal of Obstetrics and Gynaecology Research·Masaki KiyomuraMasaharu Ito
Mar 26, 2005·Immunology Letters·José Manuel Rodríguez-PérezGilberto Vargas-Alarcón
Mar 21, 2017·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Dulce Brito
Mar 13, 2014·Journal of Veterinary Internal Medicine·F TablinM D Kittleson
Aug 17, 2010·Journal of Veterinary Internal Medicine·B KornreichT Divers
Nov 24, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Zhixin GuoJohn H McNeill
May 18, 2016·Journal of Cardiovascular Medicine·Giuseppina NovoMaria Penco
Oct 19, 2016·Journal of Cardiovascular Medicine·Giuseppina NovoMaria Penco
Sep 10, 2020·International Journal of Molecular Sciences·Emanuele MondaGiuseppe Limongelli
Jun 5, 2018·Heart Failure Reviews·Monika BartekovaNaranjan S Dhalla
Aug 10, 2013·Journal of Nuclear Medicine Technology·Lioe-Fee de Geus-OeiHanneke W M van Laarhoven
Aug 14, 2021·Frontiers in Cardiovascular Medicine·Elysa JuiK Jane Grande-Allen
Sep 22, 2007·Metabolism: Clinical and Experimental·Zhixin GuoJohn H McNeill

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