Comparison of clinical and three-dimensional histomorphometric optic disc margin anatomy.

Investigative Ophthalmology & Visual Science
Nicholas G StrouthidisClaude F Burgoyne

Abstract

To investigate the anatomic basis of the optic disc margin in the normal monkey eye by colocalizing optic disc photographs to three-dimensional (3D) histomorphometric reconstructions of the same optic nerve head. Optic disc photographs from 28 normal monkey eyes were overlaid onto 3D central retinal vessel reconstructions generated as part of postmortem optic nerve histomorphometric reconstructions for each eye. Within each reconstruction, the Bruch's membrane opening (BMO) was delineated. Alignment was achieved by matching the clinical vessel outline to the vessel reconstruction with parallel viewing software. An experienced observer viewed stereophotographs and marked the disc margin onto clinical photographs with custom software. Alignment of the delineated disc margin to the histomorphometrically defined BMO was qualitatively assessed within each image. In 20 eyes, BMO aligned well to the disc margin delineation. In four eyes, alignment improved after repeated colocalization. Careful review of the histomorphometric reconstructions identified that in most cases Bruch's membrane extended beyond the termination of the border tissue of Elschnig, most substantially in the superior and nasal sectors. Misalignments could be explai...Continue Reading

Associated Clinical Trials

Citations

Jul 16, 2013·Japanese Journal of Ophthalmology·Young Hoon HwangJoo Hwa Lee
Sep 24, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yan TengBaisheng Dai
Jul 14, 2010·Survey of Ophthalmology·Matthew T WitmerMitchell Drucker
May 12, 2010·Acta Ophthalmologica·Jost B Jonas
Jan 1, 2014·Acta Ophthalmologica·Jost B JonasSonghomitra Panda-Jonas
Sep 10, 2015·Journal of Ophthalmology·Joshua S HardinGianmarco Vizzeri
Jul 26, 2015·Neuroimaging Clinics of North America·Jade S SchiffmanRosa A Tang
May 12, 2018·Acta Neuropathologica Communications·Melissa L CooperDavid J Calkins
Jun 28, 2011·Journal of Glaucoma·Nisreen K MesiwalaShan C Lin
Jan 7, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hideo NakanishiAkitaka Tsujikawa
Mar 21, 2017·European Journal of Ophthalmology·Antonio LongoMichele Reibaldi
Oct 3, 2017·European Journal of Ophthalmology·Antonio LongoMichele Reibaldi
Aug 15, 2018·Acta Ophthalmologica·Lucas A TorresBalwantray C Chauhan
Dec 22, 2019·Scientific Reports·Mi Sun SungSang Woo Park
Jan 1, 2018·Ophthalmology. Glaucoma·Mohamed S SayedRichard K Lee

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