Comparison of clinical categories for Escherichia coli harboring specific qnr and chromosomal-mediated fluoroquinolone resistance determinants according to CLSI and EUCAST

Enfermedades infecciosas y microbiología clínica
Jesús MachucaA Pascual

Abstract

EUCAST breakpoints are more restrictive than those defined by CLSI. This study highlights the discrepancies between CLSI and EUCAST in a well characterized isogenic Escherichia coli collection and their correlations with specific quinolone resistance mechanisms. The greatest number of discrepancies was observed in strains containing 2-4 resistance mechanisms (MIC values on the borderline of clinical resistance). Bearing in mind that quinolones are concentration dependent antimicrobial agents, small changes in MIC may have relevant consequences for treatment outcomes.

References

Aug 8, 2007·Antimicrobial Agents and Chemotherapy·Sonia K Morgan-Linnell, Lynn Zechiedrich
Sep 15, 2009·Current Topics in Medicinal Chemistry·Karl DrlicaXilin Zhao
Oct 5, 2010·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·José Manuel Rodríguez-MartínezAlvaro Pascual
Aug 21, 2014·The Journal of Antimicrobial Chemotherapy·Jesús MachucaJosé-Manuel Rodríguez-Martínez

❮ Previous
Next ❯

Citations

Feb 19, 2016·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·José-Manuel Rodríguez-MartínezJosé Luis Fernández

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.