Comparison of clinical stage, therapy response, and patient outcome between squamous cell carcinoma and adenocarcinoma of the esophagus.

International Journal of Gastrointestinal Cancer
Pooja R RohatgiJaffer A Ajani

Abstract

To analyze the differences in clinical stage, pathologic response to chemoradiotherapy, patterns of failure, and overall survival (OS) between patients with squamous cell carcinoma (SCC) and adenocarcinoma (ACA) of the esophagus. We stratified patients by two histologies, ACA and SCC, and statistically compared their clinical stage, post-therapy pathologic response, patterns of failure, and OS. Of the 235 patients who underwent preoperative chemoradiotherapy, 42 (18%) had SCC and 193 (82%) had ACA. Among the ACA patients, a significantly larger proportion was male (93% vs 7%; p <0.001), whereas sex was distributed similarly among SCC patients (55% male vs 45% female; p = 0.5). A significantly larger percentage of SCC patients were classified as lower TN and overall stage than ACA patients (T2 = 41% vs 28%, p <0.0001; N0 = 69% vs 48%, p = 0.01; stage II = 76% vs 55%, p <0.001). A significantly greater portion of SCCs was categorized as pathologic N0 after treatment (71% vs 65%; p = 0.02). Among the pathCR patients in clinical stage II, there were significantly greater proportion of SCC patients (77% vs 63%; p <0.001) than ACA patients. Among the pathCR patients in clinical stage III patients, a significantly greater proportion w...Continue Reading

Citations

Sep 30, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arta Monir MonjazebA William Blackstock
Feb 6, 2009·Annals of Surgical Oncology·Björn L D M BrücherJaffer A Ajani
Jul 1, 2011·Journal of Visceral Surgery·D TougeronC Silvain
Oct 9, 2009·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·B L D M Brücher
Mar 5, 2009·Journal of Cancer Research and Clinical Oncology·Andreas-Claudius HoffmannJan Brabender
Jun 6, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Julie G IzzoJaffer A Ajani

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