PMID: 15227560Jul 1, 2004Paper

Comparison of closed-loop and open-loop models in the assessment of cardiopulmonary and baroreflex gains

Methods of Information in Medicine
R TakaloI Korhonen

Abstract

Both open- and closed-loop models of beat-to-beat cardiovascular control have been suggested. We tested whether the modelling yields different results with real data while assessing cardiopulmonary and baroreflex gains. Two autoregressive models are described to resolve causal relationships between systolic blood pressure (SBP), RR-interval (RRI) and instantaneous lung volume (ILV): a closed-loop model which takes into account both the RRI changes induced by changes in SBP and the SBP changes mediated by changes in RRI, and an open-loop model which does not have a link from RRI to SBP. The performance of the models was compared in 14 healthy men in supine and standing positions under control conditions and under conditions of beta -sympathetic and parasympathetic pharmacological blockades. Transfer function gains were computed from ILV to RRI (cardiopulmonary gain) and from SBP to RRI (baroreflex gain). The measurements were done under controlled random-interval breathing. The gains identified by the open-loop model tended to be higher than those from the closed-loop model, but the differences did not reach statistical significance. Importantly, the two models discriminated the changes in transfer gains between different interv...Continue Reading

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