PMID: 9449284Feb 4, 1998Paper

Comparison of CO2 generation (BACTEC) and viable-count methods to determine the postantibiotic effect of antimycobacterial agents against Mycobacterium avium complex

Antimicrobial Agents and Chemotherapy
G G ZhanelA M Kabani

Abstract

The postantibiotic effects (PAEs) of antimycobacterial agents determined with a BACTEC TB-460 instrument (CO2 production) and by a traditional viable-count method against Mycobacterium avium complex (MAC) were not significantly different (P > 0.05). The longest PAEs following a 2-h exposure to 2x the MIC were induced by amikacin (10.3 h), rifampin (9.7 h), and rifabutin (9.5 h), while the shortest PAEs resulted from clofazimine (1.7 h) and ethambutol (1.1 h) exposure. CO2 generation is a valid and efficient means of determining in vitro PAEs against MAC.

References

Dec 1, 1986·Antimicrobial Agents and Chemotherapy·L B HeifetsP J Lindholm-Levy
Nov 1, 1971·Postgraduate Medical Journal·D A Mitchison, J M Dickinson
May 1, 1993·Antimicrobial Agents and Chemotherapy·S Y TsuiA F Cheng

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Citations

Nov 16, 2001·Antimicrobial Agents and Chemotherapy·C Y ChanA F Cheng
Jul 27, 2004·Antimicrobial Agents and Chemotherapy·Ronald N JonesDouglas J Biedenbach

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