Comparison of commercial and experimental porcine circovirus type 2 (PCV2) vaccines using a triple challenge with PCV2, porcine reproductive and respiratory syndrome virus (PRRSV), and porcine parvovirus (PPV)

Vaccine
H G ShenT Opriessnig

Abstract

The efficacies of commercial porcine circovirus type 2 (PCV2) vaccines and a live PCV1-2a chimeric vaccine were compared in conventional, PCV2-positive piglets using a PCV2-porcine reproductive and respiratory syndrome virus (PRRSV)-porcine parvovirus (PPV) coinfection challenge model. Seventy-three, 2-week-old pigs were randomized into seven groups including five vaccinated and two control groups. Pigs in the vaccinated groups were vaccinated at 3 weeks (one dose) or at 3 and 6 weeks (two dose) of age. All vaccine regimens tested were effective in reducing naturally occurring PCV2 viremia at 16 weeks of age and after PCV2 challenge, demonstrating the capability of the products to induce a lasting protective immunity despite the presence of PCV2 viremia at the time of vaccination.

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Citations

Dec 14, 2011·Animal Health Research Reviews·T OpriessnigP G Halbur
Oct 1, 2011·Virus Research·Tanja Opriessnig, Patrick G Halbur
Apr 9, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Chunya WeiGuihong Zhang
Jan 1, 2013·Annual Review of Animal Biosciences·Xiang-Jin Meng
Oct 23, 2016·Veterinary Microbiology·Zahra AfghahSheela Ramamoorthy
Sep 4, 2007·Advances in Virus Research·Susan F Cotmore, Peter Tattersall
Sep 24, 2011·Clinical and Vaccine Immunology : CVI·K C O'NeillT Opriessnig
Mar 25, 2011·Clinical and Vaccine Immunology : CVI·Benjamin R TribleRaymond R R Rowland
Feb 1, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·María Soledad SerenaJavier Cappuccio

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