Comparison of community-onset Staphylococcus argenteus and Staphylococcus aureus sepsis in Thailand: a prospective multicentre observational study

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
N ChantratitaSharon J Peacock

Abstract

Staphylococcus argenteus is a globally distributed cause of human infection, but diagnostic laboratories misidentify this as Staphylococcus aureus. We determined whether there is clinical utility in distinguishing between the two. A prospective cohort study of community-onset invasive staphylococcal sepsis was conducted in adults at four hospitals in northeast Thailand between 2010 and 2013. Of 311 patients analysed, 58 (19%) were infected with S. argenteus and 253 (81%) with S. aureus. Most S. argenteus (54/58) were multilocus sequence type 2250. Infection with S. argenteus was more common in males, but rates of bacteraemia and drainage procedures were similar in the two groups. S. argenteus precipitated significantly less respiratory failure than S. aureus (5.2% versus 20.2%, adjusted OR 0.21, 95% CI 0.06-0.74, p 0.015), with a similar but non-significant trend for shock (6.9% versus 12.3%, adjusted OR 0.46, 95% CI 0.15-1.44, p 0.18). This did not translate into a difference in death at 28 days (6.9% versus 8.7%, adjusted OR 0.80, 95% CI 0.24-2.65, p 0.72). S. argenteus was more susceptible to antimicrobial drugs compared with S. aureus, and contained fewer toxin genes although pvl was detected in 16% (9/58). We conclude that...Continue Reading

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Citations

Apr 5, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M A ArgudínO Denis
Oct 22, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·N ChantratitaT E West
May 18, 2018·Journal of Medical Microbiology·Erika Tång HallbäckLiselott Svensson Stadler
Jul 20, 2017·The American Journal of Tropical Medicine and Hygiene·Alicia D YeapAngela M Kearns
Jan 8, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Abiola SenokRalf Ehricht
Jun 24, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Farah AlhusseinCihan Papan
Jul 17, 2020·Journal of Bone and Joint Infection·Bo SöderquistMarc Stegger
Jul 29, 2020·Antimicrobial Agents and Chemotherapy·Arnold S Bayer, Steven Y C Tong
Sep 19, 2018·Emerging Infectious Diseases·Josselin RigaillPaul O Verhoeven
Mar 1, 2018·Frontiers in Microbiology·Ayodele OlatimehinFrieder Schaumburg
Jun 21, 2018·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Hege Smith TunsjøAina E F Moen
Feb 26, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Leonie E A BankRoel H T Nijhuis

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Methods Mentioned

BETA
PCR
genotyping
electrophoresis

Software Mentioned

lustal
rc GIS
Stata
MEGA
BioNumerics

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