Comparison of comorbid depression between irritable bowel syndrome and inflammatory bowel disease: A meta-analysis of comparative studies

Journal of Affective Disorders
Qin GengYu-Tao Xiang

Abstract

The prevalence of comorbid depression is high in chronic gastrointestinal disorders, including irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). For these two disorders in particular, the findings have not been consistent. This meta-analysis systematically compares the rates and severity of comorbid depression between IBS and IBD patients. A systematic literature search was conducted using PubMed, PsycINFO, Embase, Cochrane Library, Wan Fang, SinoMed, Chinese National Knowledge Infrastructure from their inception date to September 12, 2017 for comparative studies on IBS and IBD patients. Standardized mean differences (SMDs) and odds ratios (OR) of comorbid depression were calculated using random effect models. Data on comorbid anxiety in the included studies were also extracted and analyzed. Altogether, 22 studies with 1,244 IBS and 1,048 IBD patients were included. While there was no significant group difference in the prevalence of depression (10 studies, OR = 1.18, 95%CI: 0.87-1.60, P = 0.29), the IBS group had more severe depression (pooled SMD = 0.18, 95%CI: 0.04-0.33, P = 0.01) and anxiety than the IBD group (pooled SMD = 0.31, 95%CI: 0.14-0.49, P = 0.0006). Sixteen (72.7%) studies were assessed as 'hig...Continue Reading

Citations

Mar 5, 2019·The Clinical Journal of Pain·Carrie FallingRamakrishnan Mani
Jul 12, 2019·Journal of Psychopharmacology·Wei ZhengYu-Tao Xiang
Nov 22, 2019·The Australian and New Zealand Journal of Psychiatry·Joshua D RosenblatAndre F Carvalho
Sep 26, 2020·Frontiers in Psychology·Gabriella MartinoC M Vicario
Feb 26, 2020·International Journal of Environmental Research and Public Health·Mario Rivera-IzquierdoJosé Juan Jiménez-Moleón
Dec 12, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Angela AnconaFranco Scaldaferri
Jun 1, 2021·Cellular and Molecular Neurobiology·Gerald A HigginsJohn W Wiley

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