PMID: 8962517Oct 1, 1996Paper

Comparison of contact site cancer potency across dose routes: case study with epichlorohydrin

Risk Analysis : an Official Publication of the Society for Risk Analysis
Gary L GinsbergD B Hattis

Abstract

Risk assessment for airborne carcinogens is often limited by a lack of inhalation bioassay data. While extrapolation from oral-based cancer potency factors may be possible for some agents, this is not considered feasible for contact site carcinogens. The change in contact sites (oral: g.i. tract; inhalation: respiratory tract) when switching dose routes leads to possible differences in tissue sensitivity as well as chemical delivery. This research evaluates the feasibility to extrapolate across dose routes for a contact site carcinogen through a case study with epichlorohydrin (EPI). EPI cancer potency at contact sites is compared across three bioassays involving different dose routes (gavage, drinking water, inhalation) through the use of dosimetry models to adjust for EPI delivery to contact sites. Results indicate a large disparity (two orders of magnitude) in potency across the three routes of administration when expressed as the externally applied dose. However, when expressed as peak delivered dose, inhalation and oral potency estimates are similar and overall, the three potency estimates are within a factor of seven. The results suggest that contact site response to EPI is more dependent upon the rate than the route of d...Continue Reading

References

Nov 1, 1978·Pharmacology, Biochemistry, and Behavior·H KuribaraT Miura
Feb 1, 1991·Regulatory Toxicology and Pharmacology : RTP·W E Pepelko
Jun 1, 1990·Risk Analysis : an Official Publication of the Society for Risk Analysis·D Hattis
Feb 9, 1990·Journal of Theoretical Biology·C C TravisR C Ward
Aug 1, 1990·Toxicology and Applied Pharmacology·R H ReitzM L Gargas
May 1, 1989·British Journal of Industrial Medicine·S Paterson, D Mackay
Mar 15, 1989·Toxicology and Applied Pharmacology·M L GargasM E Andersen
Jan 1, 1986·Annual Review of Public Health·S H Moolgavkar
Jan 1, 1987·Archives of Environmental Health·T UmezuA Shimizu
May 1, 1987·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J D deBethizyC B Frederick
Oct 1, 1987·Environmental Health Perspectives·J K HasemanE E McConnell
Jan 1, 1986·International Archives of Occupational and Environmental Health·V Fiserova-Bergerova, M L Diaz
Jan 1, 1985·Journal of Toxicology and Environmental Health·N A Littlefield, D W Gaylor
Sep 1, 1985·Toxicology·P W WesterG J Van Esch
Nov 1, 1974·Journal of Applied Physiology·E F AharonsonD F Proctor
Aug 1, 1984·The American Review of Respiratory Disease·K T MorganE A Gross
Aug 1, 1984·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·W T Stott, M J McKenna
Dec 1, 1984·Environmental Health Perspectives·L S GoldR Peto
Jul 1, 1984·Toxicology and Applied Pharmacology·L A BuckleyC S Barrow
Aug 1, 1983·Mutation Research·A M RossiC Pantarotto
Oct 1, 1980·Journal of the National Cancer Institute·S LaskinR E Albert
Feb 1, 1981·Postgraduate Medical Journal·J D HorowitzW J Louis
Apr 1, 1994·American Journal of Respiratory and Critical Care Medicine·G J PoianiD J Riley
Nov 1, 1993·Toxicology and Applied Pharmacology·J B MorrisK T Blanchard
May 1, 1993·Journal of Toxicology and Environmental Health·L S Gold, T H Slone

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Citations

Dec 31, 1997·Mutation Research·M S BogdanffyA E Harman
Dec 1, 2007·Journal of Toxicology and Environmental Health. Part a·Katherine WalkerGary Ginsberg
Nov 16, 2013·Journal of Hazardous Materials·Ianina R Hutler WolkowiczCristina S Pérez Coll

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