PMID: 8986972Dec 1, 1996Paper

Comparison of continuous infusion of fentanyl to bolus dosing in neonates after surgery

Journal of Pediatric Surgery
P R VaughnK K Denver

Abstract

Concern about respiratory depression may lead to underuse of postoperative narcotic analgesia in neonates. The authors compared continuous infusion of fentanyl with bolus dosing in infants after surgery to determine whether continuous infusion is associated with less respiratory depression. In the first phase of the study, 16 patients were randomly assigned to receive fentanyl by continuous infusion (C) or bolus dosing every 2 hours (B) in a double-blinded trial. Respiratory events were recorded. An observational pain score and saliva for cortisol concentration were obtained 2, 8, and 24 hours after beginning treatment to compare efficacy of pain control. In the second phase, 20 additional patients received fentanyl by continuous infusion in an unblinded fashion, with the same data collection, to more accurately determine the incidence of respiratory events. In phase 1, apnea occurred in eight of nine B patients (89%) compared with one of seven C patients (14%; P < .009), prompting termination of the randomized trial. The incidence of apnea or significant respiratory depression in the next 20 patients (phase 2) who received fentanyl by continuous infusion was 25% (5 of 20; P < .01 v B). Episodes of apnea in B patients required ...Continue Reading

References

Apr 28, 1979·British Medical Journal·E N Fry
Aug 1, 1992·Journal of Pediatric Surgery·B NaylorD McLaughlin
Nov 19, 1987·The New England Journal of Medicine·K J Anand, P R Hickey
Jan 1, 1986·Journal of Pain and Symptom Management·M E Owens
Jul 1, 1986·Anaesthesia·R J BrayJ A Seviour
Mar 5, 1981·Clinica Chimica Acta; International Journal of Clinical Chemistry·T UmedaT Sato
Jul 1, 1993·Critical Care Medicine·R Katz, H W Kelly

❮ Previous
Next ❯

Citations

Oct 4, 2002·The New England Journal of Medicine·Charles B Berde, Navil F Sethna
Jan 22, 2010·Pediatric Research·Xavier DurrmeyerPeter C Rimensberger
Sep 2, 2014·Pediatrics and Neonatology·Gian Maria Pacifici
Nov 28, 2012·Seminars in Fetal & Neonatal Medicine·Brian S Carter, Patrick M Jones
Mar 1, 2008·Acta Paediatrica·H M SammonsI Choonara
Apr 20, 2006·Seminars in Fetal & Neonatal Medicine·Sinno H P Simons, K J S Anand
Aug 25, 2005·Clinical Therapeutics·Charles B BerdeDick Tibboel
Mar 15, 2002·Anesthesiology Clinics of North America·Sabine Kost-Byerly
Oct 17, 2002·Clinics in Perinatology·Anna Taddio
Oct 13, 2016·The American Journal of Hospice & Palliative Care·Joseph Sacco, Rebecca Virata
Jul 24, 2001·Scandinavian Journal of Clinical and Laboratory Investigation·N NelsonE Theodorsson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.