Comparison of continuous subcutaneous insulin infusion (CSII) and multiple daily injections (MDI) in paediatric Type 1 diabetes: a multicentre matched-pair cohort analysis over 3 years

Diabetic Medicine : a Journal of the British Diabetic Association
B I JakischGerman/Austrian DPV Initiative and Working Group for Paediatric Pump Therapy

Abstract

To conduct a multicentre, matched-pair cohort analysis comparing glycaemic control and adverse events of continuous subcutaneous insulin infusion (CSII) with multiple daily injections (MDI) in paediatric patients. Using standardized computer-based prospective documentation, HbA(1c), insulin dose, body mass index-standard deviation score (BMI-SDS), rate of hypoglycaemia, rate of diabetic ketoacidosis (DKA) and intensity of care were analysed in 434 matched pairs during a follow-up period of 3 years after initiation of MDI or CSII. HbA(1c) was significantly lower in the CSII group during the first year of new regimen (CSII 7.5 +/- 0.05 vs. MDI 7.7 +/- 0.06; P < 0.05), but rose to the same level as in the MDI group during year 3. Insulin requirement remained significantly lower in the CSII group. The BMI-SDS increased in both study groups, with no significant difference. The rate of severe hypoglycaemia decreased significantly after the change of regimen (CSII 17.87 +/- 2.85 vs. MDI 25.14 +/- 3.79; P < 0.05) and during year 3 of the regimen, particularly when compared with baseline (-21% vs. -16%). The rate of DKA was lower at baseline in the CSII group and remained significantly lower over all 3 years. Intensity of care was the s...Continue Reading

References

Jul 1, 1992·Statistics in Medicine·T J Cole, P J Green
Oct 16, 2002·The Journal of Pediatrics·Jean LittonMichael Freemark
Mar 29, 2003·Diabetes Care·Jill Weissberg-BenchellRoopa Seshadri
Jun 26, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·P Scuffham, L Carr
Sep 3, 2004·The Journal of Pediatrics·Linda A DiMeglioErica A Eugster
Oct 19, 2004·Health Technology Assessment : HTA·J L ColquittN Waugh
Nov 11, 2005·Clinical Trials : Journal of the Society for Clinical Trials·Mark C SimmondsSimon G Thompson
Jun 16, 2006·Pediatric Diabetes·Ragnar Hanas, Johnny Ludvigsson
Mar 21, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·K D BarnardT C Skinner
Jul 26, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·T M KapellenR W Holl
Oct 31, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·R Rushmer, D Voigt

❮ Previous
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Citations

Jun 30, 2009·Journal of Inherited Metabolic Disease·M B PassageE D Kakkis
Aug 21, 2012·Current Diabetes Reports·Masakazu HiroseKatie Weinger
Jun 11, 2010·Diabetes Technology & Therapeutics·Kimberly FuldDarrell M Wilson
Apr 27, 2013·Diabetes Technology & Therapeutics·Neale D CohenJonathan Shaw
Jul 1, 2010·Experimental Diabetes Research·Vasiliki Valla
Oct 27, 2012·International Journal of Pediatric Endocrinology·Neesha Ramchandani, Rubina A Heptulla
Jun 3, 2009·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Dag Helge FrøislandTrond Markestad
Sep 1, 2011·Diabetes Research and Clinical Practice·Olga KordonouriThomas Danne
May 22, 2010·Diabetes Research and Clinical Practice·Yelena P WuAdela C Mitchell
Sep 8, 2009·The Journal of Pediatrics·Ilene Fennoy
Apr 7, 2011·Pediatric Diabetes·Maria FritschUNKNOWN German Competence Network Diabetes Mellitus and the DPV Initiative
Apr 7, 2011·Pediatric Diabetes·M A O'ConnellF J Cameron
Jan 1, 2010·Pediatric Diabetes·Sarah J Comeaux, Sarah S Jaser
Jul 6, 2014·Pediatric Diabetes·Nicole ScheuingUNKNOWN German/Austrian Diabetes Prospective Documentation Initiative
Sep 4, 2014·Pediatric Diabetes·Włodzimierz ŁuczyńskiUNKNOWN PolPeDiab Polish Research Group
Jun 12, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·T C Skinner, F J Cameron
Feb 19, 2013·Computer Methods and Programs in Biomedicine·Davide Capozzi, Giordano Lanzola
Dec 3, 2014·Diabetes Research and Clinical Practice·N H BirkebaekUNKNOWN Danish Society for Diabetes in Childhood and Adolescence
May 16, 2012·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·C HasselmannF Labarthe
Oct 16, 2014·Diabetes Technology & Therapeutics·Christine J OrrRobyn L Houlden
Apr 11, 2009·The Diabetes Educator·Gary ScheinerKaren Green
Jan 9, 2018·Journal of the Endocrine Society·Lisa R LetourneauSiri Atma W Greeley
May 22, 2018·Pediatric Diabetes·N H BirkebaekUNKNOWN Nordic Childhood Diabetes Registry Study Group, NordicDiabKids
Jul 4, 2018·Scandinavian Journal of Clinical and Laboratory Investigation·Anna KadłubiskaWłodzimierz Łuczyński
Jul 31, 2018·Diabetic Medicine : a Journal of the British Diabetic Association·T C Evans-CheungR G Feltbower
Feb 9, 2018·Health Expectations : an International Journal of Public Participation in Health Care and Health Policy·Claire ReidyAnne Rogers
Jul 25, 2018·Pediatric Diabetes·Jennifer L SherrDavid M Maahs
Oct 20, 2018·Artificial Organs·Ralf SchielAntje Steveling
Jan 28, 2009·Diabetes/metabolism Research and Reviews·Daniela BruttomessoAldo Baritussio
Oct 15, 2010·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Chaker Ben SalemKamel Bouraoui

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