PMID: 1203840Jul 1, 1975Paper

Comparison of continuously infused 5-fluorouracil with bolus injection in treatment of patients with colorectal adenocarcinoma

Cancer
P SeifertV K Vaitkevicius

Abstract

In a randomized series of 70 patients with with colo rectal adenocarcinoma, a comparison of systemic 5-fluorouracil chemotherapy administered as a continuous 120-hours infusion vs. intravenous bolus injection daily for 5 days demonstrated superiority of prolonged intravenous infusion. The most striking advantage of prolonged infusion of 5-FU was the absence of myelotoxicity. Fifteen of the 34 patients treated with infusion and 8 of the 36 patients treated by bolus injection developed objective tumor responses. The difference in response rate at least in part is explainable by unequal distribution of patients with different characteristics between the two treatment groups.

References

Jan 1, 1972·Journal of Surgical Oncology·G J HillF J Ansfield
Dec 1, 1966·Cancer·I D BrossR Jones
Mar 30, 1957·Nature·C HEIDELBERGERJ SCHEINER
Jan 1, 1961·Cancer·V K VAITKEVICIUSR W TALLEY
Mar 26, 1964·The New England Journal of Medicine·J E MURRAYP FRIEDMAN
Oct 15, 1958·Proceedings of the National Academy of Sciences of the United States of America·S S CohenJ Lichtenstein

❮ Previous
Next ❯

Citations

Jan 1, 1981·Cancer Chemotherapy and Pharmacology·R M FoxD Sampson
Jan 1, 1989·Cancer Chemotherapy and Pharmacology·G MilanoF Demard
Jan 1, 1988·Journal of Cancer Research and Clinical Oncology·T RiemenschneiderA Elmouaouy
Jan 1, 1994·Cancer Chemotherapy and Pharmacology·E Poplin, L Baker
Jan 1, 1991·Cancer Chemotherapy and Pharmacology·S TakedaH Hayatsu
May 1, 1993·Investigational New Drugs·N B HaasP J O'Dwyer
Aug 1, 1987·World Journal of Surgery·C M Balch, B Levin
Mar 1, 1981·Diseases of the Colon and Rectum·N D NigroB Considine
Sep 6, 2005·Journal of Cancer Research and Clinical Oncology·Hans ChristiansenOlivier Pradier
Apr 30, 1995·International Journal of Radiation Oncology, Biology, Physics·G D WeinsteinD M Ota
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R L PoorterC H Veenhof
Jun 1, 1979·Cancer Treatment Reviews·R M FoxG W Brodie
Dec 21, 2000·International Journal of Radiation Oncology, Biology, Physics·V K MehtaJ C Poen
Feb 21, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P RougierM Ducreux
Jan 1, 1985·Cancer Drug Delivery·F Valeriote, T Vietti
Apr 25, 2000·American Journal of Clinical Oncology·G CarteiF Mazzoleni
Oct 18, 2001·Anti-cancer Drugs·P G Johnston, S Kaye
Jun 1, 1979·British Journal of Clinical Pharmacology·R E FinchA F Lant
Feb 1, 1992·Australian and New Zealand Journal of Medicine·A WirthJ Zalcberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.