Comparison of conventional sonographic signs and magnetic resonance imaging proton density fat fraction for assessment of hepatic steatosis

Scientific Reports
Mimi KimDae Won Jun

Abstract

This study correlated conventional ultrasonography (US) signs with the magnetic resonance imaging (MRI) proton density fat fraction (PDFF) to evaluate the diagnostic performance of US signs (alone or combined) to predict presence and degree of hepatic steatosis (HS). Overall, 182 subjects met the study inclusion criteria between February 2014 and October 2016. Four US signs were evaluated independently by two radiologists. MRI PDFF was defined as the average of 24 non-overlapping regions of interest (ROIs) within eight liver segments obtained by drawing three ROIs within each segment. The latter acted as the reference standard to evaluate diagnostic accuracy of the US signs and their combinations. Diagnostic performance of US for HS was assessed using receiver operating characteristic (ROC) curve analyses. There was a strongly positive correlation between some combinations of US signs and PDFF (σ = 0.780, p < 0.001). The sensitivity, specificity, PPV, and NPV were 96.6%, 74.8%, 64.8%, and 97.9%, respectively, determined using abnormal hepatorenal echoes to detect grade 1 or higher HS (area under the ROC curve = 0.875). The sensitivity and NPV for detecting HS with US were good and US may be considered a suitable screening tool ...Continue Reading

References

May 20, 1998·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·R KutcherJ F Reinus
Aug 29, 2002·Gastroenterology·Sherif SaadehMichael J Sheridan
Sep 19, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·U L MathiesenG Bodemar
Dec 11, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Charlotte K RyanAmadeo Marcos
Jun 18, 2003·The American Journal of Gastroenterology·Jeanne M ClarkAnna Mae Diehl
Sep 23, 2003·The American Journal of Gastroenterology·Stephen A HarrisonPaul H Hayashi
Jun 9, 2005·Gastroenterology·Vlad RatziuUNKNOWN LIDO Study Group
Oct 29, 2008·Seminars in Liver Disease·Mariana Lazo, Jeanne M Clark
Sep 17, 2009·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Xiaozhou MaDushyant V Sahani
Oct 23, 2009·Journal of Hepatology·Srinivasan DasarathyArthur J McCullough
Oct 1, 2010·The New England Journal of Medicine·Giovanni TargherEnzo Bonora
May 28, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ruben HernaezJeanne M Clark
May 23, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mazen NoureddinRohit Loomba
Dec 6, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Steven C LinRohit Loomba
Dec 9, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rohit LoombaUNKNOWN San Diego Integrated NAFLD Research Consortium (SINC)
Apr 8, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Fernando BrilKenneth Cusi
Aug 1, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Peter BannasScott B Reeder
May 5, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Varun TakyarYaron Rotman
Sep 12, 2017·Radiology·Takeshi YokooUNKNOWN RSNA-QIBA PDFF Biomarker Committee
Oct 14, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael S MiddletonUNKNOWN NASH Clinical Research Network
Jan 23, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Cyrielle CaussyRohit Loomba

❮ Previous
Next ❯

Citations

May 21, 2019·Expert Review of Gastroenterology & Hepatology·Stefano BallestriGiampiero Francica
May 10, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tao WangDan Li
Nov 3, 2020·World Journal of Gastroenterology : WJG·Alejandro Campos-MurguíaRicardo U Macías-Rodríguez

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

mDixon
PiView
HYPERLINK
Medcalc
IDEAL IQ
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.