Comparison of Corneal Collagen Cross-Linking Protocols Measured With Scheimpflug Tomography

Cornea
Mehdi ShajariThomas Kohnen

Abstract

To evaluate the effectiveness of corneal collagen cross-linking with Dresden and accelerated protocols to treat keratoconus by Scheimpflug tomography. Fifty-eight eyes with manifest keratoconus were measured preoperatively at least twice with the Pentacam. The difference of relevant variables for keratoconus progression (eg, D value, thinnest pachymetry, Kmax) was established. After evident progression, patients underwent corneal cross-linking (29 eyes with the Dresden protocol and 29 eyes with the accelerated protocol). Postoperatively, variables used for defining manifest progression were compared again by measuring the difference between 2 measurements. Preoperatively, the mean D value was 9.6 ± 4.8 for the Dresden cohort and 8.3 ± 5.1 for the accelerated cohort. There was no significant difference between both cohorts in terms of the mean preoperative difference in the D value (0.59 ± 1.7 for the Dresden cohort vs. 0.4 ± 1.49, P = 1). Postoperatively, however, a significant difference (P < 0.01 for the accelerated corhort) was found (Dresden: -0.47 ± 0.88 vs. accelerated: 0.04 ± 0.67). Regression analysis showed that keratoconus progression was significant in both study groups preoperatively (with a significant reduction of...Continue Reading

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Citations

Aug 4, 2018·Investigative Ophthalmology & Visual Science·Daizong WenJinhai Huang
Aug 11, 2020·Journal of Ophthalmology·Cristina Ariadna NiculaAdriana Elena Bulboacă
Feb 6, 2020·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Nikolaos DervenisMiltos Balidis

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